单质碘促进的β-酮酸酯、查尔酮以及醋酸铵的三组分反应合成多取代吡啶  

Iodine-Promoted Three-Component Reaction of β-Keto Esters, Chalcones and Ammonium Acetate for the Synthesis of Poly-substituted Pyridines

作　　者：赵玉英[1] 王二兵[1] 王颖莉[2] 

机构地区：[1]太原科技大学化学与生物工程学院,太原030021 [2]山西中医学院中药药理学系,太原030024

出　　处：《有机化学》2017年第4期866-872,共7页Chinese Journal of Organic Chemistry

基　　金：山西省科技攻关(No.20130313015-2)资助项目~~

摘　　要：发展了一种单质碘促进的三组分反应,以β-酮酸酯、查尔酮以及醋酸铵为底物,构筑多取代吡啶.本方法具有原料廉价易得,底物范围广,反应操作简便等特点.A three-component reaction for the synthesis of poly-substituted pyridines from fl-keto esters, chalcones and am- monium acetate promoted by iodine has been reported. Advantages of the present method include ready availability of starting materials, broad scope of substrates, and convenience of operation.

关 键 词：单质碘 多组分反应 吡啶 

分 类 号：O626.32[理学—有机化学]