新型碳硫双手性含吡啶结构的邻苯二甲酰胺类化合物的设计、合成与生物活性研究  

Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives

作　　者：孟祥德[1] 周沙[1] 解永涛 赵毓[1] 熊丽霞[1] 周莎[1] 李正名[1] 

机构地区：[1]南开大学元素有机化学研究所元素有机化学国家重点实验室,天津30071

出　　处：《有机化学》2017年第4期908-913,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学青年基金(No.21602118);天津化学化工协同创新中心资助项目~~

摘　　要：为了开发高效、低毒、环境友好型绿色生态杀虫剂,通过研究含有两个手性中心的硫亚胺和亚磺酰亚胺类结构的构效关系,引入吡啶环,设计合成了新型碳硫双手性含吡啶结构的邻苯二甲酰胺类化合物,其结构通过NMR,HRMS分析确认.初步的生测结果表明,大部分化合物表现中等的杀虫活性.本结果为含有双手性硫亚胺和亚磺酰亚胺结构的双酰胺类化合物的研究奠定了一定的理论基础.In order to find efficient, low toxicity, eco-friendly insecticides, novel chiral carbon and sulfur phthalic acid dia- mide derivatives containing pyridine substitute were designed and synthesized for further studying the structure-activity rela- tionship of dual-chiral sulfilimines and sulfoximines. Their structures were confirmed by NMR and HRMS. The preliminary results of biological evaluation showed that the most compounds exhibited moderate larvicidal activity. These results provide a theoretical basis for the study of the dicarboxamide structures containing sulfiliminyl and sulfoximinyl moieties.

关 键 词：吡啶 邻苯二甲酰胺 合成 杀虫活性 双手性 

分 类 号：TQ453[化学工程—农药化工]