FeCl_3作用下烯基醇的碘代环醚化反应:一种合成碘代环醚的简便方法  

In the Presence of FeCl_3 Reaction of Alknols with Iodine: A Convenient Synthetic Route to Iodocyclic Ethers

作　　者：范卫永[1] 余磊[2] 彭湘君[2] 刘良先[1] 

机构地区：[1]赣南师范大学化学化工学院,赣州341000 [2]赣南医学院药学院,赣州341000

出　　处：《有机化学》2017年第4期920-924,共5页Chinese Journal of Organic Chemistry

摘　　要：研究了在温和的反应条件和FeCl_3作用下,各种烯基醇与碘发生分子内碘代环化反应生成碘代环醚,收率优良.该反应具有操作简单、底物适应广、反应快和碘用量少等特点,是现有制备碘代环醚方法的良好补充.In the presence of FeC13 reaction of alkenols with iodine resulted in intramolecular addition of hydroxyl to alkenol to produce a wide range of iodocyclic ethers in good to excellent yields under mild reaction conditions. The advantages of our procedure include a decreased amount of iodine as well as short reaction times. The broad scope, mild reaction conditions, and experimental ease of this transformation have made it a valuable alternative to current available methods for the preparation of iodocyclic ethers.

关 键 词：分子内碘代环醚化反应 三氯化铁 烯基醇 

分 类 号：O621.3[理学—有机化学]