蒲地蓝消炎口服液治疗小儿化脓性扁桃体炎有效性及安全性的系统评价  

Systematic review of effectiveness and safety of pudilan Xiaoyan oral liquid in treating pediatric suppurative tonsilitis

作　　者：卞丽玲 杨丰文[1] 王媛[1] 张莉[2] 刘春香[3] 张俊华[3] 郑文科[3] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第二附属医院,天津300150 [3]天津中医药大学循证医学中心,天津300193

出　　处：《中国中药杂志》2017年第8期1482-1488,共7页China Journal of Chinese Materia Medica

基　　金：教育部新世纪优秀人才项目(NCET-13-0936);天津市青年拔尖人才项目

摘　　要：该文通过系统检索相关电子数据库,收集相关文献,对蒲地蓝消炎口服液治疗小儿化脓性扁桃体炎的有效性及安全性进行系统评价。最终纳入18篇随机对照试验,涉及1 883例化脓性扁桃体炎患儿,蒲地蓝试验组957例,抗生素对照组926例。Meta结果显示:与单独应用抗生素相比,联合服用蒲地蓝可有效提高小儿化脓性扁桃体炎治疗的总有效率,缩短患儿的体温恢复正常时间,缩短扁桃体脓性分泌物消失时间,也能减少咽痛消失时间、扁桃体肿大或充血消退时间、食欲精神恢复时间。治疗期间蒲地蓝试验组均无严重不良反应。该研究表明:与单独使用抗生素相比,联合应用蒲地蓝能更有效安全地治疗小儿化脓性扁桃体炎,但由于文献研究质量偏低,上述结论有待高质量临床试验进一步验证。The review aims to assess the effectiveness and safety Pudilan Xiaoyan oral liquid in treating pediatric suppurative tonsillitis systematically through searching relevant electronic database and collecting relevant literature.Meta-analysis was performed with the RevMan 5.3 software.Eighteen RCTs of 1 883 patients of pediatric suppurative tonsillitis were included.Meta-analysis showed that： compared with the application of antibiotics alone, combined with Pudilan can effectively improve the treatment of pediatric suppurative tonsillitis in efficacy rate and shorten the time of recovering normal temperature, the time of tonsil purulent discharge and can also reduce the extinction time of sore throat, antiadoncus or congestion subsided and appetite recovery.There was no severe adverse reaction during the treatment.Compared with the application of antibiotics alone, combined with Pudilan may be more effective and safe in the treatment of pediatric suppurative tonsillitis, which can not be strongly proved at present for lack of studies with high quality.

关 键 词：蒲地蓝 化脓性扁桃体炎 随机对照试验 系统评价 

分 类 号：R276.1[医药卫生—中医五官科学]