藿香正气方治疗胃肠型感冒有效性和安全性系统评价  

Huoxiang Zhengqi formulas for treatment of gastrointestinal type cold:a systematic review and Meta-analysis

作　　者：赵宏杰[1] 郭利平[2] 杨丰文[1] 张明妍[1] 张立双[1] 刘智[1] 李越[1] 季昭臣 郑文科[1] 张俊华[1] 

机构地区：[1]天津中医药大学循证医学中心,天津300193 [2]天津中医药大学附属保康医院,天津300193

出　　处：《中国中药杂志》2017年第8期1495-1499,共5页China Journal of Chinese Materia Medica

基　　金：教育部新世纪优秀人才项目(NCET-13-0936);天津市青年拔尖人才项目

摘　　要：系统评价藿香正气方治疗胃肠型感冒的有效性及安全性。计算机检索CNKI,Wan Fang Data,Vip,Sino Med,Pub Med,Cochrane Library,Embase数据库,搜集藿香正气方治疗胃肠型感冒的随机对照试验(RCT),检索时限均为建库至2017年3月。筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果显示共纳入8个RCT,680例患者。8个研究均报告了临床有效率指标,提示藿香正气组疗效优于单纯西药组(RR及95%,1.2[1.08,1.33]);藿香正气联合西医常规疗法疗效优于西医常规疗法(RR及95%,1.32[1.20,1.46])。在症状缓解率方面,共纳入1个研究,提示藿香正气方在改善单个症状(如恶寒、发热、肠鸣腹泻方面)优于西药,在改善咽痛咽痒症状与西药治疗差异无统计学意义。该研究没有发现藿香正气方相关不良反应。藿香正气方治疗胃肠型感冒的临床疗效优于西药组及西医常规治疗组。受纳入研究的数量和质量的影响,上述结论尚需进一步开展更多高质量研究予以验证。This systematic review aims to evaluate the efficacy and safety of Huoxiang Zhengqi formulas in treating gastrointestinal type cold.Seven electronic databases,including CNKI, WanFang Data, Vip, SinoMed, PubMed, Cochrane Library, Embase will be searched from the inception of the study until March 2017.All randomized controlled trials that evaluate the treatment of Huoxiang Zhengqi formulas for gastrointestinal type cold will be eligible.The methodological quality will be assessed using the Cochrane risk of bias tool for randomized clinical trials and Review Manager 5.3 software is used for analyzing the data.The results are： eight RCTs and 680 patients are included.Meta-analysis are performed according to the stratification of the treatment strategy.Eight studies report clinical efficacy, among them four studies show Huoxiang Zhengqi formulas are better than western medicine（RR and 95%,1.2[1.08, 1.33]）, another four studies showHuoxiang Zhengqi formulas in conjunction with conventional treatment are better than conventional treatment（RR and 95%, 1.32[1.20,1.46]）.About symptom remission rate, one study shows the treatment group effect is better than the control group from the following clinical symptoms：chills,fever,bowel diarrhea,the effect of treating sore throat itchy is same with western medicine treatment.No adverse reactions are found about Huoxiang Zhengqi formulas in this study.Current evidence shows that Huoxiangzhengqi formulas are better than Western medicine group and western medicine routine treatment group from clinical efficacy.Limited by the quantity and quality of studies, more large-scale and rigorously designed randomised controlled trials with large sample size are warranted to clarify the conclusions.

关 键 词：藿香正气 胃肠型感冒 META分析 系统评价 

分 类 号：R254.9[医药卫生—中医内科学]