天然小分子酚的抗焦虑作用研究进展  

Review on anxiolytic effect of natural small-molecule phenols

作　　者：王小红[1] 张婵溪 李贵云[2] 黄建梅[1] 翟海峰[3] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]中国科学院上海生命科学研究院,上海200032 [3]北京大学中国药物依赖性研究所,北京100191

出　　处：《中国中药杂志》2017年第8期1557-1565,共9页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81173541)

摘　　要：酚类化合物具有抗氧化、抗肿瘤、抑菌、抗炎等多种生物活性。近期有文献报道,一些黄酮类化合物对中枢神经系统有显著影响,表现出抗焦虑作用。另有研究表明,黄酮类化合物经肠道菌群代谢为相对分子质量更小的酚是黄酮类化合物产生抗焦虑作用的关键,即提示天然小分子酚类化合物具有抗焦虑作用。该文利用Sci Finder数据库,对具有抗焦虑作用的天然小分子酚进行了系统检索(截止2016年6月),总结了其抗焦虑作用特点和机制,根据化学结构对其进行分类,并对化学结构与抗焦虑作用之间的构效关系进行了讨论。Phenolic compounds have multiple bioactivities, such as anti-oxidant, anti-tumor, anti-bacterial, and anti-inflammatory activities.Recent literatures have demonstrated that flavonoids have a significant anti-anxiety effect on the central nervous system.In addition, studies showed that flavonoids acted as pro-drugs, which were transformed into smaller phenols through intestinal microflora.The small phenolic metabolites were crucial for the anxiolytic effects of these flavonoids, indicating that natural small-molecule phenols（NSMP） generally have anxiolytic activities.In this paper, the supporting evidences （before June 2016） from SciFinder database have been summarized.Furthermore, NSMPs were classified according to chemical structures;their anxiolytic effects, mechanisms, and the structure-activity relationships were also discussed.

关 键 词：天然小分子酚 抗焦虑作用 构效关系 

分 类 号：R285[医药卫生—中药学]