干细胞在子宫内膜损伤修复中的研究进展  

Research progress of stem cells in the repair of endometrial injury

作　　者：刘彩姣[1] 王蔼明[2] 

机构地区：[1]内蒙古民族大学临床医学院,内蒙古通辽028000 [2]海军总医院妇产科,北京100048

出　　处：《安徽医药》2017年第5期781-785,共5页Anhui Medical and Pharmaceutical Journal

基　　金：国家"十二五"科技支撑计划项目(2012BAI32B05);国家自然科学基金项目(81000245;81370703);全军后勤科研课题(CHJ12J012)

摘　　要：临床实践中,子宫内膜损伤与频繁的宫腔操作史、感染及部分药物的使用密切相关。严重者可能会引起子宫内膜基底层的损伤,影响子宫内膜上皮细胞和损伤血管的再生,从而导致子宫内膜修复困难。临床上可表现为月经减少,闭经,不孕,习惯性流产,早产和胎盘异常等。对于重度子宫内膜损伤的治疗是临床上较为棘手的问题,近年来国内外学者研究发现干细胞移植在子宫内膜损伤修复方面具有重要作用,细胞治疗为子宫内膜损伤后修复提供了新的思路和方向。In the clinical practice,endometrial injury is closely related to uterine cavity operation history,infection and the use of some drugs. In severe cases,uterine endometrial basal layer damage may occur,which affecting endometrial epithelial cells and vascular re-generation leading to endometrial repair difficultly. The clinical manifestations ofendometrial injury include decreasing in menstrualflow, amenorrhea,infertility,recurrent miscarriage,premature birth and placental abnormalities,etc. The therapy of severe endometrial injury is a thorny problem in clinic. In recent years, domestic and foreign scholars have found that stem cell transplantation plays an important role in the repair of endometrial injury. Cell therapy provides a new way of thinking and direction for repair of endometrial injury.

关 键 词：干细胞 子宫内膜 损伤 修复 

分 类 号：R711[医药卫生—妇产科学]