雷贝拉唑和泮托拉唑对氯吡格雷抗血小板作用的影响  

Impact of rabeprazole and pantoprazole on antiplatelet activity of clopidogrel

作　　者：陆哲远 吴继雄[1] 程诚[1] 杨婷[2] 

机构地区：[1]安徽医科大学第二附属医院心内科,安徽合肥230601 [2]安徽医科大学第二附属医院药剂科,安徽合肥230601

出　　处：《安徽医药》2017年第5期927-930,共4页Anhui Medical and Pharmaceutical Journal

基　　金：安徽医科大学校科学研究基金资助项目(2015xkj020)

摘　　要：目的探讨冠心病病人使用雷贝拉唑或泮托拉唑对氯吡格雷的抗血小板作用的影响。方法 148例冠心病病人在给予阿司匹林和氯吡格雷基础上,分成雷贝拉唑组(雷贝拉唑10 mg·d-1,n=50)、泮托拉唑组(泮托拉唑40 mg·d-1,n=48)和对照组(n=50)。比较3 d后血小板聚集率。结果三组平均血小板最大聚集率分别为雷贝拉唑组(44.4±21.1)、泮托拉唑组(39.4±21.4)、对照组(45.3±15.2),P=0.274,三组之间差异无统计学意义,三组间的氯吡格雷抵抗发生率分别为雷贝拉唑组(46.0%)、泮托拉唑组(41.7%)、对照组(38.0%),P=0.719,差异无统计学意义。结论雷贝拉唑和泮托拉唑对氯吡格雷的抗血小板活性短期内无明显影响。Objective To investigate the influence of rabeprazole and pantoprazole on antiplatelet activity of clopidogrel in patients with coronary atherosclerotic heart disease. Methods 148 patients with coronary atherosclerotic heart disease treated with aspirin and clopi-dogrel were randomly divided into rabeprazole group, pantoprazole group and control group. Adenosine diphosphate - induced platelet aggregation was measured to evaluate the antiplatelet effect of clopidogrel after 5 days in three groups. Results Adenosine diphosphate - induced platelet aggregation was similar among three groups：rabeprazole group（44. 4 ±21. 1）,pantoprazole group（ 39. 4 ±21.4） and control group（45. 3 ±15.2） 274. There was no significant difference between these groups. The incidence of clopidogrel resist-ance in three groups ： rabeprazole group （46. 0% ） , pantoprazole group （41.7% ） and control group （ 38.0%） , P =0 .719, there was no significant difference. Conclusion There are no significant impact of rabeprazole or pantoprazole on antiplatelet activity of clopidogrel.

关 键 词：雷贝拉唑 泮托拉唑 氯吡格雷 血小板聚集率 

分 类 号：R541.4[医药卫生—心血管疾病]