北京市常住居民脂质蓄积指数与高血压、糖尿病的关系  

Relationship of lipid accumulation product with hypertension and diabetes among Beijing residents study

作　　者：申元媛[1] 陈纪春[1] 李刚[2] 曹杰[1] 李建新[1] 黄建凤[1] 顾东风[1] 

机构地区：[1]北京协和医学院中国医学科学院阜外医院国家心血管病中心心血管疾病国家重点实验室流行病研究部,100037 [2]北京市疾病预防控制中心慢性病防治所,100037

出　　处：《中华预防医学杂志》2017年第5期415-420,共6页Chinese Journal of Preventive Medicine

基　　金：北京市科技计划（D09050703650901）;中国医学科学院医学与健康科技创新工程（2016-12M-3-018）

摘　　要：目的 探讨北京地区成年人脂质蓄积指数（LAP）适用公式,进一步评估LAP与高血压、糖尿病患病的关系.方法 本研究通过对2011年＆quot;北京市心脑肾及糖尿病慢性病流行病学综合调查研究＆quot;中的19606名18-79岁常住居民的横断面调查资料进行分析,分别计算北京地区成年男性和女性的最小腰围,得到LAP适用公式;采用多因素logistic回归模型分析男性和女性不同LAP水平（三分位数分组）与高血压、糖尿病的关系;按照BMI进行分组,计算男性和女性不同LAP和BMI组合下的高血压和糖尿病患病风险.结果 北京地区成年人LAP适用公式为：LAP（男）=[腰围（cm）-61.3 cm]×TG（mmol/L）,LAP（女）=[腰围（cm）-55.6 cm]×TG（mmol/L）.男性和女性的高血压、糖尿病患病风险均随着LAP水平升高而增加（P＆lt;0.001）,以低LAP水平组为参照,男性和女性高水平LAP组的高血压患病风险OR（95%CI）值分别为3.62（3.11-4.22）和5.79（4.84-6.93）,糖尿病分别为3.47（2.73-4.41）和4.10（2.90-5.80）;LAP与BMI分组组合后,与低LAP水平和非超重组相比,高LAP水平合并肥胖组的高血压和糖尿病患病风险更高,男性和女性高血压患病风险OR（95%CI）值分别为6.79（5.50-8.37）和9.75（7.76-12.25）,糖尿病患病风险OR（95%CI）值分别为3.97（2.87-5.49）和4.13（2.78-6.14）.结论北京成年人LAP与高血压和糖尿病患病密切相关,有待开展更深入的研究证实其对高血压、糖尿病发病风险的预测价值.Objective To explore the lipid accumulation product （LAP） formula for Beijing adults and to investigate the relationship between lipid accumulation product and hypertension, as well as diabetes. Methods A cross-sectional study with a representative sample of 19606 residents in Beijing aged 18-79 years was conducted in 2011. The sex-specific hypothetical minimum waist circumference （WC） was calculated in order to obtain the more applicable LAP formula. Multivariate logistic regression was used to analyze the associations of LAP, combination of LAP and body mass index （BMI） with hypertension and diabetes. Results The LAP formula for Beijing adults was established as follows：LAP （male）=（WC-61.3） × TG, and LAP （female）=（WC-55.6） × TG. There was an obvious trend of increased risk of hypertension and diabetes with an increment in the tertiles of the LAP both in men and women. The OR （95%CI）for hypertension in the group with highest tertile LAP was 3.62 （3.11-4.22） in men, and 5.79 （4.84-6.93） in women, compared with the lowest tertile group, respectively;and the corresponding OR for diabetes was 3.47 （2.73-4.41） in men, and 4.10 （2.90-5.80） in women, respectively. Compared with the lowest tertile of LAP and normal BMI group, the OR （95%CI） for hypertension in the highest tertile of LAP and obesity group was 6.79 （5.50-8.37） in men, and 9.75 （7.76-12.25） in women, respectively;while the corresponding value for diabetes was 3.97 （2.87-5.49） in men, and 4.13 （2.78-6.14） in women, respectively. Conclusion The elevated level of LAP was associated with an increased risk of hypertension and diabetes among Beijing adults. LAP could be an important predictor for hypertension and diabetes.

关 键 词：横断面研究 高血压 糖尿病 人体质量指数 脂质蓄积指数 

分 类 号：R181.3[医药卫生—流行病学] R544.1[医药卫生—公共卫生与预防医学] R587.1