基于独立成分分析的静息态MRI脑功能成像与皮层电刺激在脑部病变运动区术前定位中的对照研究  

Comparison of localizing motor area before the surgery based on resting-state functional MRI with independent component analysis and electric cortical stimulation

作　　者：孙骁俊 袁建华[2] 毛德旺[2] 张寒[4] 陈书达[3] 丁忠祥[2] 李玉梅[2] 

机构地区：[1]温州医科大学 [2]浙江省人民医院放射科,杭州310014 [3]杭州师范大学认知与脑疾病研究中心 [4]浙江省人民医院神经外科,杭州310014

出　　处：《中华放射学杂志》2017年第5期334-338,共5页Chinese Journal of Radiology

基　　金：浙江省卫生厅科研基金（WKJ2013.2-003,2013RCA001）;浙江省自然科学基金（LY13H180016,LY16H180007）;浙江省科技厅公益项目（2014C33126）

摘　　要：目的 以皮层电刺激为对照,评价基于稳定组独立成分分析（ICA）的静息态fMRI定位皮质功能区的准确性.方法 选取我院2014年1月至2015年12月脑神经外科的运动区病变患者23例,手术前采集患者脑静息态MR数据,并采用ICA算法分析得到功能区定位结果 .在排除头动过大等不符合要求的患者后,最终入组14例有效患者.以术中皮层电刺激作为皮层定位标准,比较两种技术的符合率.结果 14例患者的辅助运动区（SMA）均可以准确定位.健侧运动区,包括主运动区（M1）、运动前区（PMC）,通过ICA成分提取也可以得到明确的功能定位.在病灶一侧的脑区,运动区功能定位数量较健侧有所减少.与皮层电刺激结果 阳性位点结果 相比,基于ICA分析方法 的静息态fMRI在脑病变运动区术前定位完全符合11例（11/14）,基本符合3例（3/14）.结论 基于ICA的静息态fMRI技术在患者运动功能定位中具有较高的定位准确度,对术前功能评估及手术方案规划有较大的参考意义.Objective To evaluate the accuracy of presurgically resting-state fMRI（rs-fMRI） with subject order-independent group independent component analysis（ICA）, compared to electric cortical stimulations. Methods Twenty-three patients with the lesion in motor area, which were recorded by our hospital from Jan, 2014 to Dec, 2015, were collected as the study sample. The data of 9 patients were excluded because of excessive head motion. As a result, 14 patients were included in this study. Rs-fMRI data before the surgery and the results of electric cortical stimulations were collected. Results All of this 14 patients were preoperatively located by rs-fMRI with SOI-GICA, including all the SMA and the ipsilesional primary motor area. On the side with lesion, the number of functional location of motor area was decreased compared with healthy side. Evaluate the accuracy of ICA by comparing the coincidence rate of these two techniques, based on the standardized electrical cortical stimulation in operation. The completely concordance between rs-fMRI with the SOI-GICA and electrical cortical stimulation in operation was 11 （11/14）. Meanwhile the basically concordance of corresponded case was 3（3/14）. Conclusions Rs-fMRI with the ICA has a relatively high accuracy rate in localizing motor area. Rs-fMRI has a remarkably referential contribution to the presurgically function assessment and surgical planning in implementation.

关 键 词：磁共振成像 大脑皮质 电刺激 对比研究 

分 类 号：R445.2[医药卫生—影像医学与核医学] R651.1[医药卫生—诊断学]