血清降钙素原检测对尿路感染的临床诊断价值  

Clinical significance of serum procalcitonin in the diagnosis of urinary tract infection

作　　者：张树琛[1] 王杉[1] 朱凤霞[1] 崔亮[2] 张海红[2] 李东[1] 时琰丽[1] 李雪清[1] 鲁炳怀[1] 

机构地区：[1]民航总医院检验科,北京100123 [2]民航总医院泌尿外科

出　　处：《中国预防医学杂志》2017年第4期263-265,共3页Chinese Preventive Medicine

基　　金：北京市科技计划课题(Z141107002514036)

摘　　要：目的探讨血清降钙素原(procalcitonin,PCT)检测在尿路感染诊断中的应用价值。方法收集民航总医院2014年7月至2016年6月189例患者的临床资料,按诊断标准分为尿路感染组(n=60)和非尿路感染组(n=129),采用秩和检验或t检验比较两组间血清PCT、白细胞(WBC)和C-反应蛋白(c-reactive protein,CRP)水平的差异,并同时对60例尿路感染患者的尿培养结果进行分析。用ROC曲线判断不同指标诊断尿路感染的特异度和敏感度。结果尿路感染组血清PCT水平高于非尿路感染组,中位数分别为0.36μg/L与0.05μg/L,差异有统计学意义(P<0.05)。PCT用于诊断尿路感染的灵敏度为75.0%,特异度为82.2%,诊断准确性优于CRP与WBC。结论血清PCT水平是区分是否尿路感染及同时伴有血流感染的一个重要指标,有利于临床的早期诊断。Objective To explore the clinical significance of serum procalcitonin（PCT）detection in the diagnosis of urinary tract infection. Methods A retrospective review was conducted by collecting the clinical data and records of 189 patients from July 2014 to June 2016 in Civil Aviation General Hospital,including 60 cases with urinary tract infection（UTI）,and 129 with no UTI（Non-UTI）.The serum levels of PCT and c-reactive protein（CRP）as well as white blood cells（WBC）were determined and compared using non-parametric test and ROC curve was used to determine the best differentiating cut-off values. Results The serum level of PCT in patients with UTI was significantly higher than that in non-UTI patients（P0.05）.The sensitivity and specificity of PCT in UTI diagnosis were 75.0% and 82.2%,respectively,which was much better than WBC and CRP. Conclusions The serum PCT level may be served as a major indicator of UTI,which helps the early diagnosis of UTI.

关 键 词：降钙素原 尿路感染 ROC曲线 

分 类 号：R446.5[医药卫生—诊断学]