吡格列酮对糖尿病大鼠中枢神经系统11β-羟类固醇脱氢酶1型表达的影响  

Effects of pioglitazone on expressions of 11β-hydroxysteroid dehydrogenase type 1 in central ner-vous system of diabetic rats

作　　者：綦雯雯[1] 贾凯英[1] 孙达[1] 富晶[1] 杨敏[1] 潘磊[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院干部医疗暨老年医学科,100038

出　　处：《神经疾病与精神卫生》2017年第3期184-186,共3页Journal of Neuroscience and Mental Health

摘　　要：目的 研究吡格列酮对糖尿病大鼠海马、下丘脑处11β-羟类固醇脱氢酶1型（11β-HSD1）表达的影响及与认知功能的关系.方法 雄性SD大鼠随机分为对照组（C组）、糖尿病组（D组）、糖尿病＋吡格列酮治疗组（DP组）,每组10只.8周后行Morris水迷宫评价大鼠的认知功能,Western Blot方法检测大鼠海马、下丘脑处11β-HSD1表达水平.结果 Morris水迷宫中,D组大鼠穿越原平台区次数较C组减少,DP组大鼠较D组增多,差异有统计学意义（P＆lt;0.01）.在海马和下丘脑处,11β-HSD1表达D组较C组增加,DP组较D组减少,较C组增加,差异有统计学意义（P＆lt;0.01）.结论 吡格列酮能够降低糖尿病大鼠海马、下丘脑组织局部11β-HSD1表达水平,并且可能是吡格列酮改善糖尿病大鼠空间学习记忆能力的机制之一.Objective To study the effects of pioglitazone （PGZ） on the expressions of 11β-hydroxys-teroid dehydrogenase type 1（11β-HSD1） in central nervous system of diabetic rats and its asociation with cog-nitive function.Methods Thirty male SD rats were equally randomized into Control group （C group）, Diabetic group （D group） and Diabetes＋Pioglitazone group （DP group）. Morris-water maze was used to test the cognitive function after 8 weeks. Western Blot was used to detect the expressions of 11β-HSD1 in hippocampus and hy-pothalamus.Results In Morris water maze, the number of crossing the platform in D group were significantly less than C group and DP group （P＆lt;0.01）. The 11β-HSD1 expressions in hippocampus and hypothalamus of D group were significantly increased than C group and DP group, while the 11β-HSD1 expressions of DP group were significantly increased than C group （P＆lt;0.01）.Conclusion Pioglitazone may improve cognitive function in diabetic rats, partly through the decrease of 11β-HSD1 expressions in hippocampus and hypothalamus.

关 键 词：糖尿病 中枢神经系统 11β-HSD1 认知功能 吡格列酮 

分 类 号：R339.2[医药卫生—人体生理学]