乙肝肝硬变患者中医证型与Child-pugh分级和AFP相关性研究  

Relevant Research Between TCM Syndromes of Hepatitis B Hepatocirrhosis and Child-pugh Grading and AFP

作　　者：周萍[1] 张志勇[1] 张翠芳[1] 袁剑锋[1] 周帆[1] 

机构地区：[1]黄石市中心医院,湖北黄石435000

出　　处：《河南中医》2017年第5期824-826,共3页Henan Traditional Chinese Medicine

基　　金：黄石市科技厅资助项目(编号:2010A1015)

摘　　要：目的:探讨乙肝肝硬变患者中医证型与Child-pugh分级和AFP间的相关性,以便正确评估各型肝硬变患者病情严重程度及预后转归,为中医辨证提供量化依据。方法:通过回顾性研究收集146例乙肝肝硬变患者相关资料,根据TBIL、ALB、PT、腹水、肝性脑病计算Child-pugh分级,分析患者证型与Child-pugh分级及AFP的相关性。结果:肝气郁结型以Child-pugh分级A级为主,占71.43%,水湿内停型、湿热蕴结型以Child-pugh分级B级为主,分别占47.06%、42.50%,脾肾阳虚型、肝肾阴虚型以Child-pugh分级C级为主,分别占52.00%、62.50%。脾肾阳虚型患者AFP最高,湿热蕴结型次之,肝气郁结型最低,但各证型间差异无统计学意义。结论:Chid-pugh分级与乙肝肝硬变各型间存在一定相关性,可作为中医辨证的参考依据,协助临床判断各型患者病情严重程度;乙肝肝硬变证型与AFP的相关性有待更大样本的研究。Objective： To explore the relevance between TCM syndromes of hepatitis B hepa/ocirrhosis and Chihl-pugh grading andA in order tn corrtctly assess tile severity and prngnosis of hepatocirrhosis and provide quantitative basis for the TCM syndrome difirentiaton. Methods： The data of totally 146 patients with hepatitis B hepatnein-hosis were collected and reviewed. The （hild-pugh grading was calculated and the relevance between the syndromes and Child-pugh grading and AFP was analyzed according to TBII,, AI,B, VI＇, ascites and hepatic eneephalopathy. Results： The swldrome of liver qi depression mostly behmged to grade . of Chihl-pugh, accounting for 71.43% ; syndromes of internal retention of water dampness, accumulation of damp heat mostly be- longed to grade B, respectively accounting for 47.06% and 42.50% ; syndromes of spleen and kidney yang deficiency, liver and kidney yi. deficiency mostly behmged to grade C, respectively accounting for 52.00% and 62.50%. The AFP in patients with spleen and kidney yang del＇i＇iency was the highest, then the syndrome of accumulation of damp heal, and the syndrome of liver qi depression was the lowest. The difl＇erenees between different syndromes had no statistical significance. Conclusion： There is eer- lain relevance between Child-push grading and different syndromes of hepatitis B hepatoeirrhosis, which can he the reference fir TCM sndrome dif＇lk＇ventiation and helt） determine the severity of patients＇ condition. The relevance between the syndromes of hep- atitis B hvp;llocirrhosis and AFP needs hu＇ger sample research.

关 键 词：乙肝肝硬变 中医证型 CHILD-PUGH分级 AFP 

分 类 号：I259.751[文学—中国文学]