平肝止痛颗粒对偏头痛(肝阳上亢型)大鼠血浆中ET、PENK含量的影响  

Effect of Pinggan Zhitong Granule on ET and PENK Content in Blood Plasma of Migraine Rats with Hyperactivity of Liver-yang

作　　者：秦瑞[1] 金曦[1] 

机构地区：[1]长春中医药大学,吉林长春130117

出　　处：《中国中医急症》2017年第5期786-788,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：吉林省科学技术厅重点科技攻关项目(20150204046YY)

摘　　要：目的观察平肝止痛颗粒对肝阳上亢型偏头痛大鼠的镇痛效果,探讨其治疗偏头痛的作用机制。方法使用附子法和硝酸甘油法制作肝阳上亢偏头痛大鼠模型,通过酶联免疫法检测大鼠血浆中内皮素(ET)、前脑啡肽原(PENK)含量。结果平肝止痛颗粒高、中剂量组均能明显减少ET含量,与模型组比较差异显著。头痛宁和平肝止痛颗粒中剂量组可以减少PENK含量,与模型组比较有明显差异。结论平肝止痛颗粒可以有效降低肝阳上亢型偏头痛,其作用机制可能与降低血浆中ET、PENK的含量有关。Objective： To observe the analgesic effect of Pinggan Zhitong Granule on ET and PENK content in blood plasma of migraine rats with hyperactivity of liver-yang and discuss the mechanism of its effect on migraine. Methods： Migraine rats with hyperactivity of liver-yang models were set up with Radix Aconiti Lateralis Preparata and nitroglycerin method. ET and PENK content in rats blood plasma was detected by ELISA. Results： Compared with blank group and model group,Pinggan Zhitong Granule high dose and medium dose group could reduce ET content obviously and there was significant difference with the model group. Toutoagning and Pinggan Zhitong Granule medium dose group could reduce PENK content and the result showed significant difference compared with the model group. Conclusion： Pinggan Zhitong Granule can effectively alleviate liver-yang hyperactivity migraine. Its mechanism may be related to its down-regulating effect on the ET and PENK content in blood plasma.

关 键 词：平肝止痛颗粒 偏头痛 内皮素 脑啡肽 镇痛 

分 类 号：R285.5[医药卫生—中药学]