自拟中药方剂穴位贴敷结合美沙拉嗪栓治疗溃疡性结肠炎急性发作的疗效观察  

Clinical Curative Effect Observation of Self-made Acupoint Application of Traditional Chinese Medicine Combined with Mesalamine Suppository in the Treatment of Acute Attack of Ulcerative Colitis

作　　者：郭颂铭[1] 宋献文[1] 

机构地区：[1]上海市同济医院,上海200065

出　　处：《中国中医急症》2017年第5期883-886,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：上海市科学技术委员会课题(16401971400)

摘　　要：目的对自拟中药方剂穴位贴敷结合美沙拉嗪栓治疗溃疡性结肠炎急性发作的临床疗效进行研究。方法将本院收治的102例溃疡性结肠炎急性发作患者随机分为对照组和联合组,各51例,对照组患者给予单用西药美沙拉嗪栓进行治疗,联合组患者在对照组西药治疗的基础上采用自拟中药方剂穴位贴敷,从而比较对照组和联合组患者的治疗前后中医症状分级量化积分差异,血沉、血红蛋白及C反应蛋白水平(CRP),肿瘤坏死因子-α(TNF-α)、白介素-17(IL-17)、白介素-23(IL-23)炎症细胞因子水平,临床疗效及复发率。结果联合组患者治疗后中医症状分级量化积分均显著低于对照组(P<0.05);联合组治疗后的血沉和血红蛋白水平较对照组治疗后显著改善(P<0.05),但两组CRP差异无统计学意义(P>0.05);联合组治疗后的TNF-α、IL-17、IL-23炎症细胞因子水平均显著低于对照组(P<0.05);联合组的临床疗效的总有效率要显著优于对照组(P<0.05);联合组的病症复发率要显著低于对照组(P<0.05)。结论自拟中药方剂穴位贴敷结合美沙拉嗪栓治疗溃疡性结肠炎急性发作,有助于改善其中医证候,改善血沉、血红蛋白及CRP,降低TNF-α、IL-17、IL-23炎症细胞因子水平,从而提高临床疗效,降低治疗后复发率。Objective： To study the elinieal effect of serf-made aeupoint application of traditional Chinese medieine combined with Mesalamine suppository in the treatment of acute attack of ulcerative colitis. Methods： 102 eases of aeute attack of ulcerative colitis were randomly divided into the control group （n = 51 ） and the eom- bination group （n = 51）. The control group were treated with oral Mesalamine suppository,and the combination group were treated with serf-made acupoint application of traditional Chinese medicine on the basis of Mesalamine suppository treatment. The following data was compared between the control group and the combination group before and after the treatment： traditional Chinese medieine symptoms elassifieation of differences,the levels of ESR,Hb and CRP,the levels of TNF-α,IL-17,IL-23,clinical efficacy and recurrence rate. Results： After treatment,TCM symptom quantified points in the combination group were significantly lower than those of the eontrol group （P〈 0.05）;after treatment,the levels of ESR and Hb in the combination group were improved more significantly than those of the eontrol group （P〈0.05）,but there was no significant difference in the level of C reactive protein between the two groups （P〉 0.05）;after treatment,the levels of TNF-α,IL-17,and IL-23 in the combination group were signifieandy lower than those of the control group （P〈 0.05 ）;the elinieal curative effect and the total effieieney of the eombination group was signifieantly higher than that of the control group （P〈 0.05） ;the reeurrenee rate of the combination group was significantly lower than that of the control group （P〈 0.05）. Conclusion： Self-made aeupoint application of traditional Chinese medicine combined with Mesalamine suppository treatment on acute attack of uleerative eolitis can significantly improve the classification of TCM symptoms quantitative differences of scores and the levels of ESR ,Hb and CRP,and reduee the levels of inflam- matory eytokines in

关 键 词：自拟中药方剂穴位贴敷 美沙拉嗪栓 溃疡性结肠炎急性发作 疗效观察 

分 类 号：R574.62[医药卫生—消化系统]