奥美拉唑引发严重过敏反应致死亡  

Death attributed to severe anaphylactic reaction due to omeprazole

作　　者：邱志宏[1] 马银玲[1] 赫立恩[1] 董占军[1] 

机构地区：[1]河北省人民医院药学部,石家庄050051

出　　处：《药物不良反应杂志》2017年第2期147-148,共2页Adverse Drug Reactions Journal

摘　　要：1例61岁女性患者因胃部不适口服奥美拉唑肠溶片40 mg、1次/d,用药第3天出现散在皮疹,自行停用该药.3 d后皮疹有所好转,患者再次按原剂量服用该药.再次用药2 d后患者相继出现全身皮疹、严重腹泻、呕吐、急性肾损伤和过敏性休克.诊断为奥美拉唑所致严重过敏反应.经抗过敏、稳定循环、补液、连续静脉-静脉血液透析滤过等治疗无效,家属放弃治疗后次日患者死亡.A 61-year-old female patient with stomach discomfort received omeprazole enteric coated tablet 40 mg once daily.On day 3 of administration of omeprazole, she presented sporadic erythema and stopped the medicine by herself.Three days after drug withdrawal, her symptom of erythema improved.She received omeprazole enteric coated tablet at the previous dosage again.Two days after taking medicine again, the patient developed rash all over her body, severe diarrhea and vomiting, acute renal injury and allergic shock in succession.She was diagnosed as severe allergic reaction due to omeprazole.The patient received the treatments of antianaphylaxis, maintaining the function of circulatory system, fluid infusion, and continuous veno venous hemodiafiltration.But the therapeutic effect was poor.The patient died on the second day after giving up the treatment which decided by her family members.

关 键 词：奥美拉唑 过敏反应 死亡 

分 类 号：R595.3[医药卫生—内科学]