制何首乌标准饮片的均匀化工艺研究  

Study on homogenized technology for standardized decoction pieces of the processed Polygonum multiflorum

作　　者：翟文泽 任晶[1,2,3] 孟江[1] 王淑美[1,2,3] 肖永庆[4] 梁生旺[1,2,3] 

机构地区：[1]广东药科大学中药学院,广东广州510006 [2]国家中医药管理局中药数字化质量评价技术重点研究室,广东广州510006 [3]广东高校中药质量工程技术研究中心,广东广州510006 [4]中国中医科学院中药研究所,北京100700

出　　处：《广东药科大学学报》2017年第2期172-176,共5页Journal of Guangdong Pharmaceutical University

基　　金：国家科技部科技基础性工作专项(2014FY111100-6)

摘　　要：目的优选制何首乌标准饮片的均匀化工艺。方法以出粉率为指标进行单因素考察,再在此基础上设计L_9(3~4)正交试验,以出粉率、粒度跨距、醇溶性浸出物、二苯乙烯苷和游离蒽醌的质量分数,以及指纹图谱总峰面积为指标,对投药体积、单次打粉时间、打粉次数3个影响因素进行考察,优选制何首乌标准饮片的均匀化工艺。结果优选出最佳均匀化工艺条件为:投药体积占打粉机体积的2/3,单次打粉40 s,打粉2次。结论优选出的最佳均匀化工艺稳定,合理可行,可为制何首乌标准饮片均匀化技术规范的制定提供参考依据。Objective To investigate the optimal homogenized technology for standardized decoction pieces of the processed Polygonum multiflorum. Methods L9（ 3^4） orthogonal experiments was designed on the basis of single factor experiments with flour yield as the index. Taking flour yield, span of particle size, ethanol soluble extraction, the contents of trans-2, 3, 5, 4＇ -tetrahydroxylstilbene-2-O-β-D-glucoside and free anthraquinone, and the total peak area of HPLC fingerprint chromatogram as the indexes, the factors of medicinal material volume in the universal pulverizer, crushing time and frequency were investigated. Results The optimal uniform technology were as follows： 2/3 volume of the universal pulverizer, running 40 s for 2 times. Conclusion The optimal crushed technology uniformly is stable, reasonable, feasible, which could provide the reference for the homogenized technical specifications of standardized decoction pieces of the processed Polygonum multiflorum.

关 键 词：制何首乌 标准饮片 均匀化工艺 综合评分 

分 类 号：R283.6[医药卫生—中药学]