Platinum drugs:from Pt(Ⅱ)compounds,Pt(Ⅳ)prodrugs,to Pt nanocrystals/nanoclusters  

作　　者：Xi Hu Fangyuan Li Nabila Noor Daishun Ling 

机构地区：[1]Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharrnaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Key Laboratory of Biomedical Engineering of the Ministry of Education,College of Biomedical Engineering&Instrument Science,Zhejiang University,Hangzhou 310027,China

出　　处：《Science Bulletin》2017年第8期589-596,共8页科学通报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2016YFA0203600);the National Natural Science Foundation of China(51503180,5161101036);“Thousand Talents Program”for Distinguished Young Scholars(588020*G81501/048);Fundamental Research Funds for the Central Universities(520002*172210161)

摘　　要：Platinum(Pt) based drugs, such as cisplatin, are widely used as anti-cancer agents, but their severe adverse reactions and resistance of cancer patients have limited their board clinical use. For the last few decades, Pt(Ⅱ) compounds, Pt(Ⅳ) prodrugs as well as smart drug delivery systems have been developed to overcome these problems. However, most conventional strategies rely on the similar anti-cancer mechanism with cisplatin and consequently only achieve limited success. Recently, Pt nanocrystals/nanoclusters(Pt NCs), with a brand new anti-cancer mechanism, have shown a promising potential in targeted cancer therapy, especially in Pt resistance circumvention. This review is helpful to understand the research strategies of Pt drugs, particularly, the recent developments and medical applications of Pt NCs.Platinum （Pt） based drugs, such as cisplatin, are widely used as anti-cancer agents, but their severe adverse reactions and resistance of cancer patients have limited their board clinical use. For the last few decades, Pt（II） compounds, Pt（IV） prodrugs as well as smart drug delivery systems have been devel- oped to overcome these problems. However, most conventional strategies rely on the similar anti-cancer mechanism with cisplatin and consequently only achieve limited success. Recently, Pt nanocrystals/nan- oclusters （Pt NCs）, with a brand new anti-cancer mechanism, have shown a promising potential in tar- geted cancer therapy, especially in Pt resistance circumvention. This review is helpful to understand the research strategies of Pt drugs, particularly, the recent developments and medical applications of Pt NCs.

关 键 词：Platinum Pt(Ⅱ) Pt(Ⅳ) Pt nanocrystals/nanoclusters Pt resistance Cancer therapy 

分 类 号：TQ460.4[化学工程—制药化工] O614.826[理学—无机化学]