中华疣海星化学成分的研究  

Chemical constituents of Pentaceraster chinensis

作　　者：李虎[1,2] 陆云阳 孙雨芊 冯颖达 汤海峰[1] 涂宏海[3] 

机构地区：[1]第四军医大学药物研究所,西安710032 [2]中国人民武装警察8673部队,山西运城044000 [3]新疆军区联勤部药品仪器检验所,乌鲁木齐830063

出　　处：《中南药学》2017年第4期409-412,共4页Central South Pharmacy

基　　金：国家自然科学基金(No.81473132)

摘　　要：目的研究中华疣海星的化学成分。方法样品用75%乙醇提取,所得浸膏经石油醚和正丁醇依次萃取,正丁醇萃取物经硅胶柱色谱、RP-C_(18)柱色谱、Sephadex LH-20凝胶柱色谱和半制备高效液相色谱等分离方法得到单体化合物,根据波谱特征和理化性质鉴定化合物的结构。结果分离鉴定了5个单体化合物,分别为asterubine(1)、cholest-3β,6α,8β,15β,24α-pentol(2)、3β,4β,6α,8β,15β,24α-hexahydroxy-cholestan-22-en(3)、pentacerasteroside A(4)和asteronyl pentaglycoside sulfate(5)。结论所有化合物均是首次从该动物中分离得到。Objective To investigate the chemical constituents of Pentaceraster chinensis. Methods The samples were extracted with 75% EtOH, and the residue was suspended in H20 and extracted with petroleum ether and n-butanol sequentially. The n-butanol section was isolated by silica gel, RP-C18, and Sephadex LH- 20 column chromatographiess, and semi-preparative HPLC. The structures of the isolated compounds were identified by chemical and spectroscopic methods. Results Five compounds were separated and identified as asterubine （1）, cholest-3β, 6α, 8β, 15β, 24α-pentol （2）, 3β, 4β, 0α, 8β, 15β, 24α-hexahydroxy-cholestan-22-en （3）, pentacerasteroside A （4）, and asteronyl pentaglycoside sulfate （5）. Conclusion All the compounds have been isolated from Pentaceraster chinensis for the first time.

关 键 词：中华疣海星 化学成分 甾体 

分 类 号：R284[医药卫生—中药学]