亚临床甲状腺功能减退症与2型糖尿病患者糖尿病视网膜病变相关性研究  

Relationship between subclinical hypothyroidism and diabetic retinopathy in type 2 diabetic patients

作　　者：齐琪[1] 张秋梅[1] 李春君[1] 董荣娜[1] 李金金[1] 郭娟娟[1] 时健英[1] 于德民[1] 张景云[1] 

机构地区：[1]天津医科大学代谢痛医院内分泌研究所卫生计生委激素与发育重点实验室天津市代谢性疾病重点实验室,300070

出　　处：《中华眼底病杂志》2017年第3期235-239,共5页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金（81300665）

摘　　要：目的 观察探讨亚临床甲状腺功能减退症（SCH）与2型糖尿病（DM）患者DM视网膜病变（DR）之间的相关性。 方法 792例2型DM（T2DM）住院患者纳入研究。其中，男性448例，女性344例；平均年龄（54.13±13.06）岁；平均DM病程（8.03±6.70）年。根据DR程度、甲状腺功能（甲功）进行分组分析。无DR（无DR组）483例，占61.0%；轻度DR（轻度DR组）240例，占30.3%；重度DR（重度DR组）69例，占8.7%。甲功正常（甲功正常组）725例，占91.5%；SCH（SCH组）67例，占8.5%。比较无DR组、轻度DR组、重度DR组患者之间SCH患病率差异以及甲功正常组、SCH组患者之间DR患病率差异。多因素logistic回归分析SCH与DR的相关性。 结果 无DR组、轻度DR组、重度DR组患者之间SCH患病率比较，差异无统计学意义（χ2=1.823，P=0.402）。SCH组、甲功正常组患者之间DR患病率比较，差异无统计学意义（χ2=1.618，P=0.239）。Logistic回归分析结果显示，SCH与不同程度DR均无相关性[轻度DR：比值比（OR）=1.361，95%可信区间（CI）=0.773～2.399，P=0.286；重度DR：OR=1.326，95%CI=0.520～3.384，P=0.555；DR：OR=1.353，95%CI=0.798～2.294，P=0.261]。 结论 SCH与T2DM患者DR无明显相关性。Objective To investigate the relationship between subclinical hypothyroidism （SCH） and diabetic retinopathy （DR） in patients with type 2 diabetes mellitus （T2DM）. Methods A total of 792 patients of T2DM were enrolled in the study. There were 448 males and 344 females, with an average age of （54.13±13.06） years. The average duration of diabetes was （8.03±6.70） years. The patients were grouped according to the degree of DR and thyroid function. Among them, 483 patients （61.0%） were no DR, 240 patients （30.3%） were mild DR, 69 patients （8.7%） were severe DR. 725 patients （91.5%） were normal thyroid function, 67 patients （8.5%） were SCH. The prevalence of SCH among no DR group, mild DR group and severe DR group was compared. And the prevalence of DR between normal thyroid function group and SCH group was compared. Logistic regression analysis was used to estimate the association between SCH and DR. Results No significant differences among the three groups （no DR group, mild DR group, severe DR group） were found in the prevalence of SCH （χ2=1.823,P=0.402）. There were no significant differences in the incidences of DR between normal thyroid function group and SCH group （χ2=1.618,P=0.239）. Logistic regression analysis demonstrated that SCH was not significant associated with DR [mild DR： odds ratio （OR）=1.361, 95% confidence interval （CI）=0.773？2.399,P=0.286; severe DR：OR=1.326, 95%CI=0.520？3.384,P=0.555; DR：OR=1.353, 95%CI=0.798？2.294,P=0.261）. Conclusion SCH is not significant associated with DR in patients with T2DM.

关 键 词：糖尿病视网膜病变/病因学 甲状腺功能减退症 糖尿病 2型/并发症 

分 类 号：R581.2[医药卫生—内分泌] R587.2[医药卫生—内科学] R774.1[医药卫生—临床医学]