糖尿病视网膜病变“代谢记忆”与氧化应激的相关性研究现状  

Relationship between diabetic retinopathy ＂metabolic memory＂ and oxidative stress

作　　者：高玮[1] 李春霞[1] 

机构地区：[1]上海市中西医结合医院眼科,200082

出　　处：《中华眼底病杂志》2017年第3期327-330,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：上海市卫生和计划生育委员会中医药科研基金（2014LP068A）;蚌埠医学院研究生科研创新计划项目（Byycx1621）

摘　　要：“代谢记忆”是指糖尿病患者的高血糖水平如果在发病早期不能得到及时控制，即使后期血糖持续稳定在正常水平，糖尿病视网膜病变（DR）等慢性并发症仍然会继续发展，难以逆转。氧化应激在DR的“代谢记忆”中起关键性作用。硝化应激、糖基化终末产物、炎症、表观遗传修饰及内质网应激相互作用，促进DR“代谢记忆”发生发展。深入研究氧化应激与DR“代谢记忆”之间的相关性，可为控制DR持续发展以及寻找新的治疗靶点提供思路。Metabolic memory means if the hyperglycemia can＇t be controlled at early stage of diabetes, chronic complications such as diabetic retinopathy （DR） will continue to develop even if the blood glucose level maintains normal level at later stage. Oxidative stress plays an important role in the ＂metabolic memory＂ of DR, which interacts with the nitrative stress, advanced glycation end products, genetic modification and endoplasmic reticulum stress in the pathogenesis of DR. Further elucidation of the relationship between oxidative stress and ＂metabolic memory＂ of DR can open the way for the discovery of novel therapeutic targets to prevent DR progression.

关 键 词：糖尿病视网膜病变/病理生理学 氧化性应激 内质网应激 综述 

分 类 号：R587.2[医药卫生—内分泌]