新生儿大脑两半球认知发育特征的事件相关电位研究  

An event related potential study on the characteristics of cognitive development of newborn＆#39;s cerebral hemispheres

作　　者：张琴芬 屠文娟 李红新 董选[2] 

机构地区：[1]江苏省常州市儿童医院新生儿科,213003 [2]江苏省常州市儿童医院儿童健康研究中心,213003

出　　处：《中华神经科杂志》2017年第5期338-341,共4页Chinese Journal of Neurology

基　　金：江苏省自然科学基金资助项目（BK20161194）;常州市科技支撑计划项目（CE20135045）

摘　　要：目的 采用事件相关电位（ERP）技术,探讨新生儿左右大脑半球认知发育特征.方法 采用抛硬币法,随机选择2013年12月至2015年10月我院新生儿科出生的健康足月新生儿（生后1-28 d）45名,健康婴儿（生后29-60 d）11名,采用ERP听觉oddball范式进行研究,对F3、F4及C3、C4导联部位N2面积、潜伏期进行比较研究.结果 生后1-28 d新生儿C3、C4导联部位N2波比较：面积（ms·μV）为5 193.68±2 137.45、4 324.51±1 334.73,差异有统计学意义（t=2.288,P=0.025）;潜伏期（ms）为764.27±216.60、878.29±294.06,差异有统计学意义（t=2.185,P=0.031）.1-28 d新生儿F3、F4导联部位N2波比较：面积（ms·μV）为5 739.44±2 271.03、5 614.87±2 280.83,差异无统计学意义;潜伏期（ms）为876.20±316.02、860.45±289.04,差异无统计学意义.生后29-60 d婴儿F3、F4导联部位N2波比较：面积（ms·μV）为7 681.35±1 723.49、5 993.55±735.63,差异有统计学意义（t=2.848,P=0.011）;潜伏期（ms）为571.60±122.48、733.40±232.73,呈现较明显的F3短于F4,但差异无统计学意义.结论 新生儿听觉感知认知左侧优于右侧,在脑中央部明显,随着日龄增大,额部也出现左侧优于右侧的特征性变化.新生儿期大脑半球认知发育已有单侧优势化表现,可能在新生儿期给予适当外界良性刺激,可以促进认知发育.Objective To investigate the characteristics of cognitive development of newborn＇s cerebral hemispheres with event related potential （ERP）. Methods Forty-five healthy full-term newborns and 11 infants of 29-60 days in the Department of Newborns, Changzhou Children＇s Hospital between December 2013 and October 2015 were randomly included in this study. They fulfilled all inclusion/exclusion criteria. An auditory oddball paradigm was used with frequently occurring ＂standand＂ tones at 1 000 Hz with 90% probability and infrequent ＂deviant＂ tones at 2 000 Hz with 10% probability. Waveforms were recorded at Fz, Cz, F3, F4, C3 and C4 scalp locations. And a comparative study of area and latency of N2 was done at F3, F4, C3 and C4 scalp locations in the two hemispheres. Results N2 wave of 1-28 days neonatal at C3, C4 scalp locations： area （ms·μV） was 5 193.68±2 137.45 vs 4 324.51±1 334.73, with statistically significant difference （t=2.288, P=0.025）;latency （ms） was 764.27±216.60 vs 878.29±294.06, also with statistically significant difference （t=2.185, P=0.031）. N2 wave of 1-28 days neonatal at F3,F4 scalp locations： area （ms·μV） was 5 739.44±2 271.03 vs 5 614.87±2 280.83, without statistically significant difference;latency （ms） was 876.20±316.02 vs 860.45±289.04, also without statistically significant difference. N2 wave of 29-60 days infants at F3, F4 scalp locations： area （ms·μV） was 7 681.35±1 723.49 vs 5 993.55±735.63, with statistically significant difference （t=2.848, P=0.011）;latency （ms） was 571.60±1.2248 vs 733.40±232.73, without statistically significant difference though F3 was shorter than F4. Conclusions The newborn＇s auditory perception cognition in the left side of central lobe is superior to the right side. With the growth of the newborn, the left side of the frontal lobe is also superior to that of the right side. Dominant hemisphere has appeared in the neonatal period. Proper stimulation can promote the newborn＇s cognitive

关 键 词：婴儿 新生 诱发电位 大脑 认知 儿童发育 

分 类 号：R722.1[医药卫生—儿科]