重组人干扰素α2b阴道泡腾胶囊联合宫颈电切术治疗宫颈上皮内瘤样病变伴高危型HPV感染的临床效果  

Clinical effect of recombinant human interferon α2b vaginal effervescent capsule combined with cervical electrosurgical excision procedure in treatment of cervical intraepithelial neoplasia complicated with high-risk HPV infection

作　　者：马小磊[1] 张雪艳[1] 范蓉[2] 

机构地区：[1]首都医科大学附属北京妇产医院药事部,北京100026 [2]广西中医药大学第一附属医院,广西南宁530023

出　　处：《中国妇幼保健》2017年第9期2011-2014,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金资助(81660429)

摘　　要：目的分析重组人干扰素α2b阴道泡腾胶囊联合宫颈电切术治疗宫颈上皮内瘤样病变(CIN)伴高危型人乳头瘤病毒(HR-HPV)感染的临床效果。方法选取76例CIN伴HR-HPV感染患者随机分为研究组和对照组各38例,对照组患者于月经结束后3~7 d时采用宫颈电切术治疗,研究组患者联合采用宫颈电切术与重组人干扰素α2b阴道泡腾胶囊治疗,1~12个月进行随访。结果治疗后研究组患者阴道出血量、阴道出血时间、阴道排液量、阴道排液时间少于对照组患者,差异有统计学意义(P<0.05);研究组患者4周内创面愈合率28.95%高于对照组患者的10.53%,8周内愈合率15.79%低于对照组患者36.84%,差异均有统计学意义(P<0.05);治疗后6个月及12个月时研究组患者的HPV-DNA转阴率81.58%及89.47%高于对照组患者的57.89%及68.42%,差异有统计学意义(P<0.05)。治疗前两组患者IL-6、TNF-α水平差异无统计学意义(P>0.05);治疗后研究组患者IL-6水平高于对照组患者,TNF-α水平低于对照组患者,差异有统计学意义(P<0.05)。研究组患者宫颈管狭窄发生率5.26%及宫颈息肉样增生发生率0.00%低于对照组患者的23.68%及21.05%,差异有统计学意义(P<0.05)。结论联合应用宫颈电切术及重组人干扰素α2b阴道泡腾胶囊治疗CIN伴HR-HPV疗效显著,可减少术后阴道出血量及排液量,加速创面愈合,促使HPV-DNA转阴,改善炎症因子水平,降低并发症发生率。Objective To analyze the clinical effect of recombinant human interferon α2b vaginal effervescent capsule combined with cervical electrosurgical excision procedure in treatment of cervical intraepithelial neoplasia （CIN） complicated with high-risk HPV （HR- HPV） infection. Methods Seventy-six CIN patients complicated with HR-HPV infection were randomly derided into study group and con- trol group, 38 patients in each group. The patients in control group were treated by cervical electrosurgical excision procedure at 3-7 days af- ter menstruation, while the patients in study group were treated by cervical electrosurgical excision procedure combined with recombinant hu- man interferon α2b vaginal effervescent capsule. All the patients were followed for 1-12 months. Results The vaginal bleeding volume, va- ginal bleeding time, vaginal discharge volume, and vaginal discharge time after treatment in study group were statistically significantly lower than those in control group （P〈0.05） . The wound healing rate within 4 weeks in study group was 28.95%, which was statistically signifi- cantly higher than that in control group （ 10. 53% ） （P〈0. 05） ; the wound healing rate within 8 weeks in study group was 15.79%, which was statistically significantly lower than that in control group （36. 84% ） （ P〈0. 05） . The negative conversion rates of HPV-DNA at 6 and 12 months after treatment in study group were 81.58% and 89.47%, respectively, which were statistically significantly higher than those in control group （57.89% and 68. 42% ） （P〈0. 05） . Before treatment, there was no statistically significant difference in IL-6 and TNF-α levels between the two groups （P〉0.05） . After treatment, IL-6 level in study group was statistically significantly higher than that in con- trol group （ P〈0. 05） ; TNF-α level in study group was statistically significantly lower than that in control group （ P〈0.05 ） . The incidence rates of cervical stenosis and cervical polypoid hyperpl

关 键 词：重组人干扰素α2b阴道泡腾胶囊 宫颈电切术 宫颈上皮内瘤样病变 高危型HPV感染 

分 类 号：R713[医药卫生—妇产科学]