不同性别老年人群高尿酸血症与代谢综合征的相关性分析  

Relationship between hyperuricemia and metabolic syndrome in elderly males and females

作　　者：高璐[1] 信中[2] 袁明霞[2] 曹曦[2] 冯建萍[2] 石敬[2] 朱晓蓉[2] 杨金奎[2] 秦明照[1] GAO Lu XIN Zhong YUAN Ming-xia et al(Department of Geriatrics ,Affiliated Beijing Tongren Hospital of Ca t）ital Medical University, Beiiine 100730, China)

机构地区：[1]首都医科大学附属北京同仁医院干部医疗科,100730 [2]首都医科大学附属北京同仁医院内分泌科,100730

出　　处：《中华老年心脑血管病杂志》2017年第5期461-465,共5页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨不同性别老年人群高尿酸血症(HUA)与代谢综合征(MS)之间的关系。方法在北京市昌平区进行的有关慢性疾病和危险因素的8084例健康调查者中,选取年龄≥60岁的调查者911例,男性409例,女性502例,男性HUA 47例和血尿酸正常(NUA)362例,女性HUA 56例和NUA 446例,进行病例对照研究。结果 911例入选者中,HUA发病率为11.30%,男女性HUA发病率比较无显著差异(11.5%vs 11.2%,χ~2=0.025,P=0.916);MS发病率为60.6%,男性MS发病率明显低于女性(44.3%vs 67.2%,χ~2=82.978,P=0.000)。MS组分为0、1、2、3、4和5个时,随MS组分增加HUA患病率明显升高(5.3%vs 7.9%vs 9.6%vs 8.2%vs 16.2%vs17.5%,χ~2=15.384,P=0.009)。女性HUA合并MS比例明显高于NUA合并MS比例(85.7%vs 72.4%,χ~2=4.558,P=0.033),男性两者无明显差异(P>0.05)。调整混杂因素后,女性HUA是MS的独立危险因素(OR=2.350,95%CI:1.020~5.416,P=0.045)。结论老年女性HUA与MS关系显著,对HUA进行积极干预治疗,有利于控制MS的发生发展,降低心脑血管事件风险。Objective To study the relationship between hyperuricemia and metabolic syndrome（MS）in elderly males and females.Methods A total of 911 subjects（409males and 502 females）aged ≥60years,selected during the investigation of risk factors for chronic diseases in Changping District of Beijing,were divided into hyperuricemia group and normal uric acid group.A case control study was performed.Results The incidence of hyperuricemia was 11.30%in the 911 subjects included in this study with no significant difference found between males and females（11.5%vs 11.2%,χ2=0.025,P=0.916）.The incidence of MS was 60.6%in these subjects and was significantly lower in males than in females（44.3%vs 67.2%,χ2=82.978,P=0.000）.The incidence of hyperuricemia increased with the number of MS components（5.3% vs 7.9% vs9.6%vs 8.2%vs 16.2%vs 17.5%,χ2=15.384,P=0.009）.The ratio of female hyperuricemia patients with MS was significantly higher than that of those without hyperuricemia but with MS（85.7%vs 72.4%,χ2=4.558,P=0.033）with no significant difference found in males.Hyperuricemia was an independent risk factor for MS after adjustment for other factors（OR=2.350,95%CI：1.020-5.416,P=0.045）.Conclusion Hyperuricemia is closely related with MS in females.Active intervention of hyperuricemia can thus control the occurrence and progression of MS and reduce the risk of cardiovascular and cerebrovascular events.

关 键 词：高尿酸血症 代谢疾病 慢性病 肥胖症 高血压 糖尿病 

分 类 号：R589[医药卫生—内分泌]