纤花线纹香茶菜化学成分的研究  

Chemical Constituents Study on Isodon lophanthoides var. graciliflora

作　　者：陈文飞[1] 陈晨[1] 夏凡[2] 师亦洁 胡丹丹[1] 李玉鹏[1] 李鲜[1] CHEN Wenfei CHEN Chen XIA Fan SHI Yijie HU Dandan LI Yupeng LI Xian(School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming 650500, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China)

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500 [2]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650204

出　　处：《云南中医学院学报》2017年第2期76-80,共5页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金(21102060);昆明医科大学2016年硕士研究生创新基金资助项目

摘　　要：目的对广东产药用植物纤花线纹香茶菜全草进行化学成分研究,以期从中发现具有药理活性的先导化合物。方法将大孔吸附树脂、硅胶、Sephadex LH-20、ODS等柱色谱与制备型高效液相色谱法相结合进行化合物的分离纯化,并通过理化性质与核磁共振波谱数据鉴定化合物的结构。结果从采自广东的纤花线纹香茶菜全草丙酮提取物中,分离鉴定了7个单体化合物,分别为2-hydroxydiplopterol(1);乌苏酸(2);乌发醇(3);豆甾醇(4);β-谷甾醇(5);dibutyl terephthalate(6);dipropyl octadecanedioate(7)。结论在对纤花线纹香茶菜全草的化学成分进行研究的过程中,分离鉴定了7个单体化合物。其中,化合物1-3为三萜类型,化合物4,5为甾醇类型,化合物6,7为结构对称的酯类化合物,且化合物1-3,6,7均为首次从该植物中分离得到。Objective To investigate the chemical constituents from the whole plant of Isodon Iophanthoides var. graciliflora which collected in Guangdong, with a view to discovering the lead compounds with pharmacological activity. Methods The chemical constituents were isolated and purified by the combination of macroporous adsorption resin, silica gel, Sephadex LH-20 and ODS column chromatography and preparative high performance liquid chromatography. Their structures were elucidated on the basis of physicochetuical properties and nuclear magnetic resonance spectroscopy data. Results Seven known compounds were isolated from the acetone extract of Isodon lophanthoides var. graciliflora. They are 2 - hydroxydiplopterol （ 1 ） ; ursolic acid （ 2 ） ; uvaol （ 3 ） ; stigmasterol （4） ; β - sitosterol （ 5 ） ; dibutyl terephthalate （6）; dipropyl octadecanedioate （7）. Conclusion Seven compounds were isolated and identified in the process of studying the chemical constituents of the whole plant. Among them, compounds 1-3 are triterpenoids, compounds 4 and 5 are sterol type, compounds 6, 7 are structurally symmetrical ester type, and 1-3, 6, 7 are isolated from the plant for the first time.

关 键 词：纤花线纹香茶菜 化学成分 三萜 甾醇 酯类 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]