氟哌噻吨美利曲辛联合心理干预在慢性阻塞性肺疾病伴焦虑抑郁患者中的应用效果  

Application effect of Flupenthixol Melitracen combined with psychological intervention in chronic obstructive pulmonary disease patients with anxiety-depression

作　　者：陈晓燕[1] 李啸 CHEN Xiaoyan LI Xiao(Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China Depart- ment of Internal Medicine, Gaoxin People＇s Hospital of Chongqing City, Chongqing 400039, China)

机构地区：[1]第三军医大学新桥医院神经内科,重庆400037 [2]重庆市高新区人民医院内科,重庆400039

出　　处：《中国医药导报》2017年第13期65-68,共4页China Medical Herald

摘　　要：目的观察氟哌噻吨美利曲辛联合心理干预在慢性阻塞性肺疾病(COPD)伴焦虑抑郁患者中的应用效果。方法选择第三军医大学新桥医院2015年1月~2016年10月收治的COPD伴焦虑抑郁患者76例按随机数字表法分为对照组和观察组,每组各38例。对照组患者给予常规抗炎、解痉、平喘、控制性氧疗、祛痰及对症支持治疗。观察组在对照组治疗的基础上加用氟哌噻吨美利曲辛,并给予心理干预。两组均以2周为1个疗程。观察两组临床疗效,比较两组患者治疗前后汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分,以及COPD评估测试(CAT)结果。结果观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组治疗后HAMA和HAMD评分均较治疗前显著下降,差异均有统计学意义(P<0.05),且观察组治疗后HAMA和HAMD评分均显著低于对照组,差异均有统计学意义(P<0.05)。对照组治疗后CAT评分与治疗前比较,差异无统计学意义(P>0.05),观察组治疗后CAT评分较治疗前显著降低,且显著低于对照组,差异均有统计学意义(P<0.05)。结论氟哌噻吨美利曲辛联合心理干预对COPD伴焦虑抑郁患者的临床疗效确切,其不仅能改善患者临床症状和焦虑抑郁状态,还能明显提高患者的生活质量。Objective To observe the application effect of Flupenthixol Melitracen combined with psychological inter- vention in chronic obstructive pulmonary disease （COPD） patients with anxiety-depression. Methods From January 2015 to October 2016, in Xinqiao Hospital, Third Military Medical University, 76 COPD patients with anxiety-depres- sion were selected, they were divided into control group and observation group by random number table, with 38 cases in each group. The control group was given conventional anti-inflammation, spasmolysis, relieving asthma, controlled oxygen therapy, eliminating phlegm and symptomatic and supportive treatment. On basis of control group, the observa- tion group was added with Flupenthixol Melitracen and psychological intervention. Both groups were taken 2 weeks as a course. The clinical effects of the two groups were observed, the scores of Hamilton anxiety scale （HAMA） and Hamil- ton depression scale （HAMD）, and the scores of chronic obstructive pulmonary disease assessment test （CAT） of the two groups before and after treatment were compared. Results The total effective rate of observation group was significantly higher than that of control group, the difference was statistically significant （P 〈 0.05）. The scores of HAMA and HAMD in the two groups after treatment were all statistically significantly lower than before treatment （P 〈 0.05）, and the scores of HAMA and HAMD in the observation group after treatment were lower than those of control group, the differences were all statistically significant （P 〈 0.05）. The scores of CAT in the control group after treatment had no statistically significant differences compared with those before treatment （P 〉 0.05）, the scores of CAT in the observa- tion group after treatment were lower than before treatment, which were also significantly lower than those of control group, the differences were all statistically significant （P 〈 0.05）. Conclusion Flupenthixol Melitracen combined with psychological in

关 键 词：氟哌噻吨美利曲辛 心理干预 慢性阻塞性肺疾病 焦虑抑郁 

分 类 号：R563.9[医药卫生—呼吸系统] R749.4[医药卫生—内科学]