单纯胶原酶与胶原酶联合臭氧治疗腰椎间盘突出症的临床对照研究  

Clinical comparative study of effects of pure collagenase and collagenase combined ozone on lumbar disc herniation

作　　者：陈建卫[1] 李晓冰[1] 宫卫东[1] 张鹏[1] 吴智群[1] 

机构地区：[1]第四军医大学唐都医院介入放射科,陕西西安710038

出　　处：《实用放射学杂志》2017年第5期742-745,共4页Journal of Practical Radiology

摘　　要：目的 探讨单纯胶原酶溶解术与胶原酶联合臭氧治疗腰椎间盘突出症（LDH）临床疗效的差异.方法 采用随机双盲对照研究,将100例LDH患者分成2组,单纯治疗组即单纯盘外胶原酶溶解术,联合治疗组即盘外胶原酶溶解术联合盘内臭氧注射,分别在术后多个时间点观察2组患者的NRS值变化及Macnab评分,分析2种治疗的疗效差异.结果 单纯治疗组50例患者中, 3例失访,联合治疗组50例患者中,2例失访,2例因疗效不佳分别于术后3月及6月行手术治疗.通过分析2组患者术前、术后的NRS值变化及Macnab评分对比,2组术后近期及远期的疗效差异无统计学意义（P＞0.05）;2组患者术后症状均较术前改善,疗效与术后恢复时间呈正相关,差异有统计学意义（P＜0.05）.结论 单纯胶原酶溶解术与胶原酶联合臭氧治疗LDH均具有显著疗效,2组治疗方式疗效差异无统计学意义.Objective To explore the therapeutic effects of pure collagenase injection and collagenase combined with herniation injection of ozone on the treatment of lumbar disc herniation（LDH）.Methods According to the principle of randomized controlled double blind, 100 patients with LDH were divided into 2 groups：pure collagenase group and combined treatment group.Changes of NRS value and Macnab score were observed and recorded at multiple time points after operation.The difference of the effect of the two kinds of operation was analyzed.Results Among the 50 patients in the simple treatment group,3 patients were lost to follow-up.Among the 50 patients in the combined treatment group,2 patients were lost to follow-up,and open surgery in 2 patients because of poor efficacy after the injection of 3 months and 6 months respectively.By analyzing the change of NRS value and Macnab score of 2 groups patients,there was no significant difference in the short-term and long-term efficacy between the 2 groups（P〉0.05）;The symptoms of the 2 groups were improved after operation.The curative effect was positively correlated with the recovery time, and the difference was statistically significant （P〈0.05）.Conclusion The curative effect of pure collagenase injection and the combined with herniation injection of ozone are both significant, and there is no significant difference in the clinical efficacy between the 2 kinds of operations.

关 键 词：胶原酶 臭氧 腰椎间盘突出症 

分 类 号：R681.53[医药卫生—骨科学] R815[医药卫生—外科学]