白塞病375例临床特点及其不同性别的临床异质性研究  

Behcet 's disease in 375 patients: clinical characteristics and gender differences

作　　者：申艳[1] 罗丹[1] 鲍华芳[1] 蔡剑飞[1] 邹峻[1] 管剑龙[1] 

机构地区：[1]复旦大学附属华东医院免疫风湿科,上海200040

出　　处：《内科理论与实践》2016年第6期366-370,共5页Journal of Internal Medicine Concepts & Practice

基　　金：上海市卫生系统重要疾病联合攻关项目(项目编号:2014ZYJB0010)

摘　　要：目的:分析我国白塞病(Behcet’s disease,BD)人群的临床特点及不同性别BD患者间的临床差异。方法:收集复旦大学附属华东医院2013年10月至2015年10月住院确诊为BD的375例患者的临床资料,分析其临床表现、系统受累及不同性别间的临床表现差异。结果:375例BD患者的平均发病年龄为(38±13)岁,平均病程为(7.69±7.39)年。口腔溃疡是患者最常见的临床症状(98.9%),其后依次为外阴溃疡(64.5%)、结节性红斑(41.6%)及眼部受累(38.7%)。BD患者的首发症状中,口腔溃疡最常见(85.3%),其后依次为结节性红斑(5.3%)、眼炎(3.2%)、生殖器溃疡(2.1%)、胃肠道溃疡(1.9%)、关节炎/关节痛(1.9%)及发热(0.3%)。临床表现上,男性BD患者的眼部病变及毛囊样皮疹明显多于女性患者(P<0.001,P=0.001)。女性BD患者的外阴溃疡发生率明显多于男性(P=0.040),女性的血液系统受累亦明显多于男性(P=0.024)。BD患者的葡萄膜炎和肠溃疡一般不并存。女性BD患者红细胞沉降率、IgG及IgM升高比例明显多于男性,差异有统计学意义(P值分别为0.001、0.012、0.009)。结论 :BD患者的临床表现多种多样,可累及多个系统,且存在性别差异。Objective To analyze the clinical characteristics of Behcet＇ s disease （BD） and the gender differences in a cohort of patients. Methods A total of 375 BD patients at Huadong Hospital from October 2013 to October 2015 were en- rolled, and the clinical manifestations, system involvement and gender differences were analyzed. Results The average age of BD onset was （38~13） years, and the average duration of disease was （7.69~7.39） years. The most common clinical manifestation was oral ulcer, followed by genital ulcer （64.5%）, erythema nodosum （41.6%） and ocular involvement （38.7%）. Oral ulcer was the most common first symptom （85.3%）, followed bY erythema nodosum （5.3%）, ophthalmia （3.2%）, genital ulcer （2.1%）, gastrointestinal ulcer （1.9%）, joint inflammatory/joint pain （1.9%） and fever （0.3%）. Gender differences in clinical manifestations revealed that more ophthalmitis and acne-like rash were seen in male （P〈0.001, P= 0.001）, and higher genital ulcer incidence and more blood system involvement were found in female patients （P=0.040, P=- 0.024）. Generally ocular damage and gastrointestinal damage didn＇t coexist. Laboratory tests showed that erythrocyte sedi- mentation rate（ESR）, IgG and IgM in female patients were significantly higher than those in males （P=0.001, 0.012, 0.009, respectively）. Conclusions The clinical manifestation of BD varies, and multiple systems may be involved. There are gen- der differences in BD clinical manifestation.

关 键 词：白塞病 性别 临床特点 

分 类 号：R597.9[医药卫生—内科学]