糖尿病肾病患者血清血小板反应蛋白-1水平变化及与相关指标的关系  

Level Changes and the Relationship between the Related Indicators of Serum TSP-1 in Diabetic Nephropathy Patients

作　　者：边志颖[1] 孙倩[1] 王君[1] 胡艳云[1] 郄海静 赵新翠 尹超[1] BIAN Zhi-ying SUN Qian WANG Jun HU Yan-yun QIE Hai-jing ZHAO Xin-cui YIN Chao(Department of Endcorionology, Baoding NO. 1 Central Hospital of Hebei Province, Baoding 071000,China)

机构地区：[1]河北省保定市第一中心医院东院内分泌三科,保定071000

出　　处：《微循环学杂志》2017年第2期55-58,66,共5页Chinese Journal of Microcirculation

摘　　要：目的:分析糖尿病肾病(DN)患者血清血小板反应蛋白-1(TSP-1)水平变化及与血脂和糖尿病有关指标的关系。方法:108例2型糖尿病(T2DM)患者,按其是否合并DN分为单纯T2DM组(T2DM组,n=52)和DN组(n=56),另选50例体检健康者为正常对照(对照组)。各组均抽取空腹肘静脉血,检测血清TSP-1、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、血脂指标甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和血浆纤维蛋白原(Fib)水平;计算胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)。比较各指标在三组间的差异,分析TSP-1与其它相关指标的相关性,回归分析TSP-1的独立危险因素及TSP-1与DN的关系。结果:三组间血清TSP-1、FBG、HbA1c、LDL-C、血浆Fib水平及FINS、HOMA-IR、HOMA-β有统计学差异,且多数表现为对照组<T2DM组<DN组。相关分析表明,TSP-1水平与FBG、HbA1c、LDL-C、Fib、FINS、HOMA-IR呈正相关,与HOMA-β呈负相关。多因素线性回归分析显示Fib、HbA1C、FINS、HOMA-β是血清TSP-1的独立影响因素,TSP-1与DN的发生有关(β=0.014,P<0.05)。结论:TSP-1水平升高与DN发生相关,下调TSP-1表达和管控TSP-1影响因素,对防治DN有重要意义。Objective： To analysis the level changes and the relationship between the blood fat and indexes related to diabetes mellitus of serum thrombospondin-1 （TSP-1） in patients with diabetic nephropathy （DN）. Method： 108 T2DM patients according to whether complicated with DN were divided into T2DM group （n=52） and DN group （n=56）, and 50 normal healthy persons for the normal control group （the control group）. Fasting venous blood was collected in each group. The TSP-1 and other clinical indicators were detected. The steady-state model was used to account for the indexes of insulin resistance（ HOMA-IR） and islet beta cell function index （HOMA-β）. To compare the differences between the three groups, analysis of the correlation between TSP-1 and other related indicators, and using regression analysis to evaluate the independent risk factors TSP-1 and the relationship between the TSP-1 with DN. Results： There was significant difference in serum TSP-1, FBG, HbA1C, LDL-C, Fib, FINS, HOMA-IR level among the three group, and most performance as the control grouP 〈T2DM group 〈DN group. Correlation analysis showed that TSP-1 level was positively correlated with FBG, HbA1C, LDL-C, Fib, FINS, HOMA-IR, and negatively correlated with HOMA-β. Multivariate linear regression analysis showed that Fib,HbA1C, FINS, HOMA-β were independent factors of serum TSP-1. TSP-1 was associated with diabetic nephropathy （β=0. 014,P〈0.05）. Conclusion： The level of TSP-1 was associated with DN. Down regulation of TSP-1 expression and control the influencing factors of TSP-1 are of great significance to the prevention and treatment of DN.

关 键 词：糖尿病肾病 血小板反应蛋白-1 血糖 血脂 胰岛素 

分 类 号：R587.2[医药卫生—内分泌]