糖化血清白蛋白对糖尿病及糖尿病前期患者的临床诊断价值  

The Clinical Value of Serum Glycated Albumin in Diabetes Mellitus and Pre-diabetes

作　　者：朱长清 石凌波[2] 康红[2] ZHU Chang-qing SHI Ling-bo KANG Hong(Guangzhou Kang Du Clinical Laboratory, Guangzhou 511442 Depatment of Laboratory, Guangzhou Univesity of Chinese Medicine, Clifford Hospital, Guangzhou 511495,China)

机构地区：[1]广州康都临床检验所,广州511442 [2]广州中医药大学祈福医院检验科,广州511495

出　　处：《微循环学杂志》2017年第2期59-61,66,共4页Chinese Journal of Microcirculation

基　　金：广东省广州市番禺区科技与信息化局基金(2012-Z-03-09)

摘　　要：目的:分析糖化血清白蛋白(GA)对2型糖尿病(T2DM)及糖尿病前期(IGR)的临床诊断价值。方法:268例糖代谢异常患者,根据WHO诊断标准分为T2DM组(n=120)和IGR组(n=148),另选同期体检健康者为对照组(n=165)。检测各组GA、空腹血糖(FBG)、餐后2h血糖(2hBG)、糖化血红蛋白(HbA1c)水平,比较组间差异;分析GA与FBG、2hBG、HbA1c水平相关性,评价GA对T2DM和IGR的诊断价值。结果:与对照组比较,IGR组和T2DM组GA、FBG、2hBG、HbA1c水平均升高,T2DM组升高更明显(P<0.01)。GA与FBG、2hBG、HbA1c水平均呈显著正相关(r=0.808、0.806、0.952,均P<0.01)。GA诊断T2DM和IGR的ROC曲线下面积(AUC)分别为0.979和0.840,诊断界值分别为17.20%和15.50%,敏感度分别为0.842和0.514,特异度分别为0.911和0.928。结论:GA水平升高或可成为T2DM和IGR的辅助诊断指标之一,尤其对T2DM,AUC更大,敏感度更高。Objective： To assess the value of glycated albumin （GA） for screening diabetes mellitus （DM） and impaired glucose regulation（IGR）. Method： 268 abnormal glucose metabolism patients were divided into type 2 diabetes mellitus （T2DM） group（n= 120） and impaired glucose regulation（IGR） group（n=148）. 165 health subjects were enrolled as control group. Fasting blood-glucose（FBG）, 2h postprandial glycemia （2hBG）, HbAlc and GA tests were analyzed for subjects in all of the three groups, and the results were compared between each groups. The correlation analysis were performed between the levels GA and the levels of FBG,2hBG, HbAlc. Results： The levels of FBG, 2hBG, HbAlc and GA were significantly higher in IGR group and T2DM group than control group（P〈0. 05）. Positive correlation was observed between GA and FBG, 2hBG and HbA1c（r=0. 808,0. 806,0. 952 respectively,P〈0.01 in all）. Using receiver operating characteristic curve （ROC curve）, the optimal cut-point of GA for diagnosis of T2DM was 17. 2%, with sensitivity was 84. 2%, specificity was 90. 7%. The area under the curve （AUC） was 0. 979 of GA. The optimal cut-point of GA for diagnosis of IGR was 15.5%, with sensitivity was 51. 4%, specificity was 95.8%, AUC was 0. 840 of GA. Conclusion： The levels of GA are significantly high in T2DM and IGR. GA may be a potential maker for diagnosis of T2DM and IGR.

关 键 词：糖化血清白蛋白 2型糖尿病 糖尿病前期 

分 类 号：R446.11[医药卫生—诊断学] R578.1[医药卫生—临床医学]