髓系细胞触发受体-1与动脉粥样硬化关系的研究进展  

Research Progress of Association between Triggering Receptor Expressed on Myeloid Cells-1 and Atherosclerosis

作　　者：陆娇[1] 李承彬[1] LU Jiao LI Cheng-bin(The Second Clinical Medical College of Yangtze University ,Jingzhou 434020, Hubei Province, Chin)

机构地区：[1]长江大学第二临床医学院,荆州434020

出　　处：《微循环学杂志》2017年第2期81-84,F0003,共5页Chinese Journal of Microcirculation

摘　　要：髓系细胞触发受体-1(TREM-1)是新近发现的免疫球蛋白超家族活化跨膜受体,能够触发和扩大炎症反应,在动脉粥样硬化(AS)的炎症机制中起重要作用。本文从TREM-1的结构特点、表达方式、配体结合、信号通路等论述其与AS发生发展及动脉斑块稳定性的关系和作用,为临床研究AS的靶向治疗提供参考和借鉴。The triggering receptor expressed On myeloid cells-1 （TREM-1） that can trigger and expand in- flammatory response is a newly discovered activating transmembrane receptor of immunoglobulin superfamily,and it plays a key role in atherosclerosis （AS）. To provide a reference or clue for targeted therapy of AS in clinical research,this review discusses effects of TREM-1 on development of AS and artery plaque stability from its structural characteristics, expression, ligand binding, signaling pathways et al.

关 键 词：髓系细胞触发受体-1 炎症反应 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]