中西医结合治疗小儿毛细支气管炎临床研究  

Clinical Study on Treatment of Infantile Bronchiolitis with Integrative Medicine

作　　者：吴秋珍 冯斌[2] 

机构地区：[1]修武县人民医院,河南修武454100 [2]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医学报》2017年第5期737-739,共3页Acta Chinese Medicine

基　　金：河南省科技攻关重大项目(112101310200)

摘　　要：目的:观察中西医结合治疗小儿毛细支气管炎痰热闭肺证的疗效及对患儿免疫功能的影响。方法:70例毛细支气管炎患儿随机分为对照组和观察组各35例。对照组给予特布他林和布地奈德雾化吸入治疗,2次·d^(-1),连续7 d。观察组在对照组治疗基础上给予定喘汤,3次·d-1,连续7 d。比较两组患者咳嗽、喘息和肺部啰音消失时间、动脉血气水平、咳嗽等症状评分及临床疗效。检测两组血清中T淋巴细胞亚群CD_3^+、CD_4^+和CD_8^+水平。结果:观察组患儿的咳嗽、喘息、肺部啰音消失时间显著短于对照组(P<0.05)。治疗后,观察组PaO_2和SaO_2明显高于对照组,PaCO_2和咳嗽等症状评分显著低于对照组(P<0.01)。观察组有效率为97.14%,对照组为77.14%,两组有效率比较,差异有统计学意义(P<0.05)。治疗后,观察组的CD_3^+、CD_4^+水平明显高于对照组,CD_8^+水平明显低于对照组(P<0.01)。结论:中西医结合治疗小儿毛细支气管炎痰热闭肺证疗效显著,且可提高患儿免疫功能。Objective： To observe the clinical efficacy of Integrative medicine in treatment of infantile Bronchiolitis with Phlegm and Heat Obstructing Lung Syndrome and the effect on their immune function. Method： Seventy cases of children patients with Bronchiolitis were randomly divided into treatment group and control group. The control group was given aerosol inhalation of terbutaline and budesonide,bid,for 7 ds. In addition to that of the control group,the treatment group was also treated with Dingchuan decoction（ 3 times/d,for 7 ds）. The extinction time of coughing,asthma and lung rale of both groups were compared. Scores of symptoms and the clinical efficacies of both groups were also compared. Besides,the serum levels of T-lymphocyte subsets CD3^＋,CD4^＋and CD8^＋were detected of the two groups. Results： The extinction time of coughing,asthma and lung rale of the treatment group was significantly lower than that of the control group（ P〈0. 05）. After treatment,PaO2 and SaO2 of the treatment group were significantly higher,while PaCO2 and symptoms score were significantly lower than that of the control group respectively（ P〈0. 01）.The total effective rate of the treatment group was 97. 14%,which was significantly higher than that（ 77. 14%） of the control group（ P〈0. 05）. After treatment,the serum levels of CD3^＋and CD4^＋of the treatment group were significantly higher,while CD8^＋was significantly lower than that of the control group respectively（ P〈0. 01）. Conclusion： The clinical efficacy of the Integrative medicine in treatment of infantile bronchiolitis with Phlegm and Heat Obstructing Lung Syndrome is significantly satisfying and the up-regulating of the immune function may play an important role during the process.

关 键 词：定喘汤 毛细支气管炎 痰热闭肺证 中西医结合 

分 类 号：R259.622.1[医药卫生—中西医结合]