β_2-MG、HbA1c和CysC检测在糖尿病早期肾损伤诊断中的临床意义  

Clinical significance of β_2-MG,glycated hemoglobin and cystain C in diagnosis of early diabetic kidney injury

作　　者：魏杰 王志国[2] 朱诚 潘振华 

机构地区：[1]上海梅山医院检验科,南京210039 [2]江苏省中西医结合医院检验科,南京210028

出　　处：《国际检验医学杂志》2017年第10期1363-1364,1367,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨β_2微球蛋白(β_2-MG)、血红蛋白(HbA1c)及胱抑素C(CysC)检测在糖尿病早期肾损伤诊断中的临床意义。方法选取2015年1-11月该院内科收治的70例糖尿病肾病患者(DN组)和110例单纯糖尿病患者(DM组)作为研究对象,与同期50例健康体检自愿者(对照组)进行对比研究。比较3组β_2-MG、HbA1c、CysC、血肌酐(SCr)及尿素(Urea)水平。结果DM组与对照组相比,SCr、Urea水平差异无统计学意义(P>0.05),而DM组β_2-MG、HbA1c及CysC水平显著高于对照组(P<0.05);DN组β_2-MG、HbA1c、CysC、SCr及Urea均显著高于对照组和DM组,差异有统计学意义(P<0.05)。DN组β_2-MG、HbA1c、CysC单一检测及3项联合检测的阳性率均显著高于DM组,差异有统计学意义(P<0.05)。结论对于糖尿病患者,β_2-MG、HbA1c及CysC能够较好反映其肾功能的早期损伤,三者联合检测有利于糖尿病的治疗和病情监测。Objective To investigate the clinical significance ofβ_2-microglobulin(β_2-MG),glycated hemoglobin(HbA1c)and cystain C(CysC)in the diagnosis of early diabetic kidney injury.Methods Seventy cases of diabetic nephropathy(group DN)and110cases of simple diabetes(group DM)admitted and treated in our hospital from June to November 2015 were selected as the research subjects and performed the contrastive study with the 50 volunteers undergoing physical examination(control group)in the same period.The levels ofβ_2-MG,HbA1 c,CysC,SCr and Urea were compared among three groups.Results Compared with the control group,the SCr and Urea levels in the DM group had no statistically significant difference(P>0.05),while theβ_2-MG,HbA1 cand CysC levels in the DM group were significantly higher than those in the control group(P<0.05);the levels ofβ_2-MG,HbA1 c,CysC,SCr and Urea in the DN group were significantly higher than those in the control group and DM group,the differences were statistically significant(P<0.05).The positive rates of single index detection and combined detection ofβ_2-MG,HbA1 c and CysC I the DN group were significantly higher than those in the DM group,and the differences were statistically significant(P<0.05).Conclusion For the patients with diabetes,β_2-MG,HbA1 cand CysC can better reflect the early damage of renal function,their joint detection is conducive to the diabetic treatment and disease condition monitoring.

关 键 词：糖尿病 肾损伤 胱抑素C Β2微球蛋白 糖化血红蛋白 

分 类 号：R446.1[医药卫生—诊断学] R587.2[医药卫生—临床医学] R692.9