黄连颗粒剂与水煎剂的主要成分和抑菌效果对比研究  

Comparison of Main Components and Antibacterial Effects of Rhizoma Coptis chinensis and Decoction

作　　者：王爽[1] 何生虎[1] 孙鹏[1] 郭亚男[1] 曹思婷[1] 张鑫[1] 

机构地区：[1]宁夏大学农学院,宁夏银川750021

出　　处：《动物医学进展》2017年第5期69-73,共5页Progress In Veterinary Medicine

摘　　要：为了对比黄连颗粒剂与水煎剂主要成分和抑菌效果,采用高效液相色谱法(HPLC)和薄层色谱法(TLC)对黄连对照药材、黄连饮片水煎剂与黄连颗粒剂中盐酸小檗碱等主要成分进行含量测定并比较,并进行了体外抑菌试验比较。结果表明,黄连颗粒剂与水煎剂所含有效成分基本一致,特征图谱在相同时间出现相似的峰,属于盐酸小檗碱特征峰;黄连煎剂和黄连颗粒剂的抑菌圈大小相似。说明在临床治疗中黄连颗粒剂可以代替黄连饮片应用。In order to compare the main components and bacteriostatic effects of Rhizoma Coptidis granules and decoction, the HPLC and TLC method were used to measure and compare the Coptis chinensis granules and elixation, the main components of berberine hydrochloridem Coptis, decoction of Coptis and other granules were determined and compared, antibacterial effects in vitro were also compared. The results showed that Rhizoma Coptidis granules and decoction of effective ingredients contained in the basic agree- ment, the characteristic spectrum of similar peak at the same time, berberine hydrochloride belongs to the characteristic peak; similar inhibitory circle of Coptis decoction and Rhizoma Coptidis granules. The results showed that Coptis chinensis granules could be used instead of coptis chinensis elixation in clinical treatment.

关 键 词：黄连颗粒剂 盐酸小檗碱 黄连水煎剂 高效液相色谱法 薄层色谱法 

分 类 号：S853.7[农业科学—临床兽医学]