益气温阳中药对腹主动脉缩窄诱导的心肾损害大鼠的干预研究  

The Therapeutic Effects of the Traditional Chinese Medicine Yi Qi Wen Yang on the Cardio-renal Damages in Rats Induced by Abdominal Aortic Coarctation

作　　者：鲁成[1,2] 谭艳[1] 宋磊[3] 蒋梅先[1] 刘永明[1] 

机构地区：[1]上海中医药大学附属曙光医院心内科,上海201203 [2]上海中医药大学附属第七人民医院心内科,上海200137 [3]安徽省六安市中医院心内科,六安237000

出　　处：《中国中西医结合肾病杂志》2017年第3期196-200,共5页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：国家自然科学基金资助项目(No.81102671);上海市高级中西医结合人才培养项目(No.ZYSNXD012-RC-ZXY002)

摘　　要：目的:探讨益气温阳中药对腹主动脉缩窄大鼠的心肾保护作用。方法:清洁级雄性Wistar大鼠40只,随机选取10只为假手术组,余30只腹主动脉缩窄术后,随机分为模型组、中药组、缬沙坦组,每组10只。造模后8周开始药物干预,共干预16周。观察药物干预对腹主动脉缩窄大鼠血压、心脏、肾脏的影响。结果:(1)左前肢血压:造模24周后,模型组SBP明显升高(P<0.05),中药组SBP较模型组降低(P<0.05),缬沙坦组SBP较模型组降低(P<0.05),中药组SBP与缬沙坦组相比差异无统计学意义(P>0.05)。(2)血流动力学:1造模24周后,模型组SAP明显升高(P<0.05),中药组SAP较模型组降低(P<0.05),缬沙坦组SAP较模型组降低(P<0.05),中药组SAP与缬沙坦组相比差异无统计学意义(P>0.05)。2造模24周后,模型组LVSP明显升高(P<0.05),中药组LVSP较模型组降低(P<0.05),缬沙坦组LVSP较模型组降低(P<0.05),中药组LVSP与缬沙坦组相比差异无统计学意义(P>0.05)。3造模24周后,模型组LVEDP明显升高(P<0.05),中药组LVEDP较模型组降低(P<0.05),缬沙坦组LVEDP较模型组降低(P<0.05),中药组LVEDP与缬沙坦组相比差异无统计学意义(P>0.05)。(3)血清BNP水平:造模24周后,模型组血清BNP值增高(P<0.05);益气温阳中药干预能降低模型大鼠的BNP水平(P<0.05);缬沙坦干预能降低BNP水平(P<0.05);益气温阳组和缬沙坦组比较,差异无统计学意义(P>0.05)。(4)血清肌酐、尿素氮水平:1造模24周后,模型组血清肌酐值增高(P<0.05);中药组血肌酐水平与模型组相比差异有统计学意义(P<0.05);缬沙坦组血肌酐水平与模型组相比差异无统计学意义(P>0.05)。益气温阳组和缬沙坦组比较,差异有统计学意义(P<0.05);2腹主动脉缩窄大鼠造模24周后各组大鼠血清尿素氮之间差异无统计学意义(P>0.05)。(5)心肌形态测量学:造模24周后,模型组大鼠CMI、LVMI明显增加(P<0.05),中药组的CMI、LVMI和模型组相比差异无统计学意�Objective ： To investigate the effects of the Traditional Chinese Medicine Yi Qi Wen Yang on the Cardio - kidney Damages in Rats by Abdominal Aortic Coarctation. Methods：Forty clean grade male Wistar rats, ten received a sham operation, while thirty with abdominal aortic Coarctation surgery were ramdomly divided into three groups： control group, TCM group and valsar- tan group. Each group consisted of ten rats. All the animals were treated for sixteen weeks when operations have been done eight weeks ago. The effects on peripheral blood pressure, cardio and renal functions would be observed. Results： （ 1 ） Peripheral blood pressure ： At the 24th week, the peripheral blood pressure of the control group was significantly increased （ P 〈 0.05 ）. Compared with the control group, the peripheral blood pressure of the TCM group and the valsartan group were reduced （ P 〈 0.05 ）. There was no significant difference between the TCM group with the Valsartan group （ P 〉 0.05 ）. （2） Hemodynamic ： ①At the 24th week, SAP of the control group was significantly increased（ P 〈 0.05 ）. Compared with the control group, the SAP of the TCM group and Valsartan group were decreased （ P 〈 0.05 ）. There was no significant difference between the TCM group with the Valsartan group （ P 〉 0.05 ）. ②At the 24th week, the LVSP of the control group was significantly increased （P 〈 0.05 ）. Compared with the control group, the LVSP of the TCM group and Valsartan group were decreased （P 〈 0.05 ）. There was no significant difference between the TCM group with the Valsartan group （P 〉 0. 05 ）. ③At the 24th week, the LVEDP of the control group was significantly increased （P 〈 0.05 ）. Compared with the control group, the LVEDP of the TCM group and Valsartan group were decreased （P 〈 0.05）. There was no sig- nificant difference between the TCM group with the Valsartan group （P 〉 0.05）. （3） BNP ： At the 24th week, the Serum BNP of the control group was i

关 键 词：益气温阳中药 腹主动脉缩窄 心肾综合征 心肾损害 

分 类 号：R285.5[医药卫生—中药学]