唑菌酯原药大鼠急性吸入毒性试验  

Acute Inhalation Toxicity of Pyraoxystrobin TC on Rat

作　　者：杨宁 吴宗澄 邹来阳 

机构地区：[1]国家沈阳新药安全评价研究中心,沈阳110021

出　　处：《农药》2017年第5期348-350,共3页Agrochemicals

摘　　要：[目的]测定唑菌酯原药对大鼠的急性吸入毒性,求出半数致死浓度(LC_(50)),为急性吸入毒性分级。[方法]参照OECD化学品测试指南中急性吸入毒性试验(NO.403,2009),以SD(Sprague Dawley)大鼠为试验动物,对唑菌酯原药进行急性吸入毒性试验。[结果]唑菌酯原药对SD大鼠急性吸入毒性试验LC_(50)值:雄性137 mg/m^3(4 h),雌性195 mg/m^3(4 h)。[结论]根据全球化学品统一分类与标签制度(GHS)大鼠急性吸入毒性分级标准,唑菌酯原药急性吸入毒性为2级,该结论为唑菌酯的安全使用提供了依据。[Aims] The aims were to determine acute inhalation toxicity of pyraoxystrobin TC on rat, calculate the median lethal concentration（LC50） and the acute inhalation toxicity classification on rat. [Methods] The test method was designed according to the OECD guideline for the testing of chemicals： acute inhalation toxicity （NO.403, 2009）. The study was performed to assess the acute inhalation toxicity of pyraoxystrobin TC on SD rat. [Results] The acute inhalation LC50 of pyraoxystrobin TC on SD rat was 137 mg/m3 （4 h） for male rat and 195 mg/m3 （4 h） for female rat. [Conclusions] According to the GHS classification criteria for acute inhalation toxicity, pyraoxystrobin TC should be classified as category 2. The conclusions provide the basis for safe use of pyraoxystrobin.

关 键 词：唑菌酯 原药 大鼠 急性吸入毒性 LC50值 

分 类 号：TQ450.261[化学工程—农药化工]