群体抗癌对癌症患者心理 生命质量和免疫功能的影响  

Effects of group anticancer on mind, quality of life and immune function of cancer patients

作　　者：陈彩霞[1] 郝睿楠 郭欣[1] 

机构地区：[1]郑州人民医院,河南郑州450000

出　　处：《临床心身疾病杂志》2017年第2期70-74,共5页Journal of Clinical Psychosomatic Diseases

基　　金：郑州市2015年度科技发展计划项目（编号20150071）

摘　　要：目的探讨群体抗癌对癌症患者心理、生命质鼍和免疫功能的影响。方法将100例拥症患者按随机数字表法分为两组，每组50例。两组患者均接受常规治疗和护理，试验组在此坫础上参加抗癌群体活动。观察12个月。于干预前后采用焦虑自评量表、抑郁自评量表及癌症生命质量核心量表评定焦虑抑郁、生命质量，并检测外周血T淋巴细胞亚群水平变化。结果干预6个月及12个月两组焦虑自评量表、抑郁自评量表评分均较干预前显著降低（P〈0．01）；癌症生命质量核心量表的躯体、角色、认知、情绪、社会功能、总体健康状况评分较干预前显著升高（P〈0．01），疲劳、疼痛、恶心呕吐、气促、失眠、食欲丧失、便秘、腹泻评分较干预前显著降低（P〈0．01）；CD8^＋水平较干预前显著降低（P〈0．01），CD3^＋、CD4^＋、CD^＋/CD8^＋较下预前显著升高（P〈0．01）。干预前两组上述方面比较差异无显著性（P〉0．05），干预后差异有显著性（P〈0．01）。结论群体抗癌能显著改善癌症患者的焦虑、抑郁情绪，减轻症状，增强其免疫能力，提高患者的生活质量。Objective To explore the effects of group antieancer on mind, quality of life and immune fune tion of cancer patients. Methods A total of 100 cancer patients were divided into two groups of 50 ones each according to random number table. Both groups received routine treatment and nursing and on this basis experimental group participated in group anticancer activities. They were observed for 12 months. Before and after intervention anxiety, depression and quality of life were assessed with the Self rating Anxiety Scale （SAS）, Self-rating Depression Scale （SDS） and the Quality of Life Core Questionnaire developed by European Organization for Research and Treatment of Cancer （EORTC QLQ-C30） respectively and changes of peripheral blood T lymphocyte subsets levels detected. Results The SAS and SDS scores of both groups lowered more significantly in the 6^th an 12^th month of intervention compared with pre-interevntion （P〈0.01） . the EORTC QLQ-C30 sores on body, role, cognition, emotion, social function and gen eral health condition heightened more significantly （P〈0.01） and those on fatigue, pain, nausea and vom iting, shortness of breath, insomnia, loss of appetite, constipation and diarrhea lowered （P〈0. 01）; CD8＋ level lowered more significantly （P〈 0. 01） and CD3^＋, CD4^＋ and CD^4＋/CD8^＋ heightened （P〈0.01）. Group differences weren＇t significant in the above-mentioned before intervention （P〈0.05） and were significant after intervention （P〈0.01）. Conclusion Group anticancer could notably improve anxious and depressive emotion of cancer patients, lighten symptoms, strengthen immuno-competence, and improve quality of life.

关 键 词：癌症 群体抗癌 情绪 生命质量 免疫功能 焦虑 抑郁 

分 类 号：R473.73[医药卫生—护理学]