生命早期黏膜免疫与呼吸变态反应易患性  

The susceptibility of allergic disorders on respiratory system based mucosal immune abnormality in the early life

作　　者：胡坚[1] 

机构地区：[1]天津市儿童医院风湿免疫科,300074

出　　处：《中华实用儿科临床杂志》2017年第9期641-644,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：共同黏膜免疫系统是变态反应免疫解剖的重基础，其作用不仅受遗传易感性调控，也受生命早期抗生素暴露的影响。生命早期暴露抗生素改变黏膜免疫防御，导致远期呼吸系统变态反应性疾病的风险已是不争的事实。就理解黏膜免疫和未来治疗的需，全面研究作为一体化的黏膜免疫系统（一个系统一组病症）是非常必的。现重点关注肺-肠跨界效应的最新研究。The common mucosal immunological system is an important anatomical basis of the allergic disor- ders. Its function is not only regulated by the susceptibility gene, but also affected the development because of the early life exposure to antibiotics. It is the tangible that early life antibiotic - driven changes in mucosal immune enhance sus- ceptibility to allergic disorders of respiratory system. A holistic approach to study the mucosal immune system as an inte- grated global organ is imperative for future advances in understanding mucosal immunology and for future treatment of the allergic disorders. This review will be focus on the latest evidence and the mechanisms in driving the lung - gut cross - talk.

关 键 词：生命早期 黏膜免疫系统 肺-肠轴 微生物群落 变态反应 支气管哮喘 

分 类 号：R725[医药卫生—儿科]