金属-生物酶共催化合成手性化合物的研究进展  

Research Progress on Co-catalysis of Metal-Bioenzyme for The Synthesis of Chiral Compounds

作　　者：王菊香[1] 李珂[1] 袁伟成[2] 陈永正[1] 

机构地区：[1]遵义医学院药学院,贵州遵义563000 [2]中国科学院成都有机化学研究所,四川成都610041

出　　处：《合成化学》2017年第5期444-456,共13页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21562054);贵州省科技厅项目(QKHRC-2016-4029;QKHRCTD-2014-4002;QKHPTRC-2016-5801)

摘　　要：综述了金属-生物酶共催化合成手性化合物的研究进展,重点介绍了金属-生物酶共催化在动态动力学拆分、串联反应和"一锅法"一步反应中的应用,并对其未来发展进行了展望。参考文献49篇。The research progress on the synthesis of chiral compounds via cooperative catalysis of met- al-bioenzyme catalyst was reviewed with 49 references. Three kinds of reactions including dynamic ki- netic resolution, cascade reaction and the ＂one pot＂ reaction were mainly described. The outlook of cooperative catalysis of metal catalyst and biocatalyst was also discussed.

关 键 词：金属-生物酶催化 动态动力学拆分 串联反应 “一锅法”反应 综述 

分 类 号：O627[理学—有机化学] O629[理学—化学]