铅神经毒性相关基因多态性的研究进展  

Gene polymorphism related with neurotoxic effects of lead:a review of recent studies

作　　者：申媛[1] 吴学文[2] 孙虹[2] 

机构地区：[1]中南大学湘雅医院肿瘤科,湖南长沙410008 [2]中南大学湘雅医院耳鼻咽喉头颈外科

出　　处：《环境与健康杂志》2017年第2期178-181,共4页Journal of Environment and Health

基　　金：国家自然科学基金青年基金(81300819);国家自然科学基金面上项目(81170912);国家重大科学研究计划(2014CB943003)

摘　　要：长期铅暴露可对人体多个器官和系统造成损伤,其神经毒性效应尤为突出。在相同的铅暴露水平下,因遗传易感性的个体差异,不同人群的铅中毒损伤程度和临床症状不尽相同。该差异可能与δ-氨基乙酰丙酸脱水酶(Deltaaminolevulinic acid dehydratase,ALAD)、维生素D受体(Vitamin D receptor,VDR)、N-甲基D-天冬氨酸受体(N-methyl-Daspartate receptor,NMDAR)及多巴胺受体D2(Dopamine receptor D2,DRD2)等基因多态性有关。该文回顾近年来国内外铅神经毒性相关基因多态性的研究,对铅的神经毒性、相关基因多态性与铅神经毒性的关系进行综述。Long-term lead exposure is hazardous to muhiple organs and systems, especially the nervous system. The population who suffered the same dose of lead exposure presented different clinical symptoms. The lead-induced injure may due to individual heredital~~ susceptibility which probably related to polymorphism of deha-aminolevulinic acid dehydratase （ALAD） gene, vitamin D receptor（VDR） gene, N-methyl-D-aspartate receptor（NMDAR） gene or dopamine D2 receptor（DRD2） gene, etc. In this paper, the neurotoxicity of lead was reviewed and the relationship between lead neurotoxicity and polymorphism was summarized.

关 键 词：铅 神经毒性 基因多态性 

分 类 号：R994.6[医药卫生—毒理学]