经皮穴位电刺激联合腔内理疗治疗肾虚型卵巢低反应临床研究  

Treatment of Poor Ovarian Response with Shen Deficiency by Transcutaneous Acupoint Electrical Stimulation Combined Intracavitary Physiotherapy

作　　者：连方[1] 李冉[2] 

机构地区：[1]山东中医药大学附属医院中西医结合生殖与遗传中心,济南250000 [2]山东中医药大学第一临床医学院,济南250000

出　　处：《中国中西医结合杂志》2017年第5期522-525,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(No.81273790;No.81473720)

摘　　要：目的探讨经皮穴位电刺激联合腔内理疗治疗体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)肾虚型卵巢低反应(poor ovarian response,POR)临床疗效。方法将92例行IVF-ET的POR患者随机分为观察组和对照组,每组46例。两组患者均采用拮抗剂方案进行IVF-ET治疗。观察组在IVF-ET超排卵周期的前1个月经周期以及超排卵过程中采用经皮穴位电刺激联合腔内理疗治疗,对照组不给予此治疗。观察两组治疗前后肾虚症状改善情况及注射人绒毛膜促性腺激素(HCG)日E_2水平、促性腺激素(gonadotropin,Gn)用量及天数、获卵数、受精率、可利用胚胎率、优质胚胎率、移植周期临床妊娠率的情况。结果与本组治疗前比较,观察组患者肾虚证候积分降低(P<0.05);治疗后与对照组比较,观察组肾虚证候积分降低(P<0.05),Gn用量减少(P<0.05),HCG日E_2水平增高(P<0.01),获卵数、受精率升高(P<0.05);与对照组比较,观察组Gn天数、可利用胚胎率、优质胚胎率及移植周期临床妊娠率差异均无统计学意义(P>0.05)。结论经皮穴位电刺激联合腔内理疗可增加IVF-ET中POR患者的获卵数,减少Gn用量,提高受精率,改善肾虚症状。Objective To observe the clinical effects of transcutaneous acupoint electrical stim- ulation combined intracavitary physiotherapy in treating poor ovarian response （POR） with Shen deficien- cy （SD） in in vitro fertilization-embryo transfer （IVF-ET）. Methods Totally 92 POR patients undergoing IVF-ET were randomly assigned to the observation group and the control group, 46 cases in each group. All patients received GnRH antagonist （GnRH-ant） protocol. Transcutaneous acupoint electrical stimula- tion combined intracavitary physiotherapy were administered to patients in the observation group during the menstrual cycle before superovulation cycle and during the superovulation process. Patients in the control group did not receive this treatment. The improvement of SD symptoms was observed before and after treatment in the two groups. Besides, the estradiol （E2） level on the day of human chorionic gonado- tropin （HCG） injection, the amount and days of using gonadotropin （Gn）, the number of retrieved oocytes, the fertilization rate, the available embryo rate, the high-quality embryo rate, and clinical pregnancy rate per embryo transfer cycle were observed. Results Compared with before treatment, scores of SD syn- drome were significantly lower in the observation group （P 〈0.05）. Compared with the control group after treatment, scores of SD syndrome significantly decreased （P 〈0.05）, Gn dosage was significantly re- duced （P 〈0.05）, the level of E2 on the day of HCG significantly increased （P 〈0.01）, the number of retrieved oocytes and fertilization rate significantly increased （P 〈0. 05） in the observation group. Compared with control group, the number of days using Gn, the available embryo rate, the high quality embryo rate, and clinical pregnancy rate per embryo transfer cycle were not significantly different in the observation group （P 〉 0.05）. Conclusion Transcutaneous acupoint electrical stimulation combined intracavitary physiotherapy could increase t

关 键 词：经皮穴位电刺激 腔内理疗 卵巢低反应 

分 类 号：R246.3[医药卫生—针灸推拿学]