血管内皮生长因子在类风湿关节炎周围神经病变患者中的应用价值  

The application value of vascular endothelial growth factor in rheumatoid arthritis patients with peripheral neuropathy

作　　者：盖楠楠[1] 

机构地区：[1]西安交通大学,西安710049

出　　处：《中国实用神经疾病杂志》2017年第9期32-34,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨血管内皮生长因子在类风湿性关节炎(类风湿关节炎)合并周围神经病变患者诊断与治疗中的应用价值。方法选取2013—2015年类风湿关节炎合并周围神经病变患者40例及仅类风湿关节炎患者40例,同时选择40例健康体检者,对受检者血清VEGF水平进行检验。结果类风湿关节炎组患者血清VEGF明显高于健康人群(P<0.05),类风湿关节炎合并周围神经病变患者VEGF水平明显高于类风湿关节炎患者(P<0.05),类风湿关节炎患者中重度与轻中度神经损伤患者血清VEGF水平无显著差异(P>0.05),类风湿关节炎患者神经损伤范围与血清VEGF无明显关系(P>0.05)。结论类风湿关节炎合并周围神经病变患者血清相比健康人群与单纯类风湿关节炎患者明显升高,VEGF水平能够提示类风湿关节炎患者是否存在周围神经病变,但无法有效标识神经受损区域及程度。Objective To explore the application value of vascular endothelial growth factor（VEGF） on rheumatoid arthritis （RA） patients with peripheral neuropathy（PN）. Methods We selected 40 patients only with RA,another 40 patients with RA and PN and 40 healthy controls in our study. The levels of serum VEFG of all recruited cases were tested. Results The level of VEGF in RA group was obviously higher than that in control group（P〈0.05）, but was significantly lower than that in RA＋ PN group （P〈0.05）. In RA＋PN group, patients with moderate-severe nerve injury had no statistical differences with those with slightmoderate injury（P〉0.05）. What＇s more,the range of nerve injury was not obviously correlated with the level of serum VEGF （P〉0.05）. Conclusion Compared with healthy people and RA patients,the patients with RA and PN may have higher level of serum VEFG, which can present whether PN exists in RA patients or not,but cannot reveal the regions of nerve injury and the severity.

关 键 词：血管内皮生长因子 类风湿关节炎 周围神经病变 

分 类 号：R593.21[医药卫生—内科学]