质谱技术在中药研究中的应用进展  

Applications Progress of Mass Spectrometry in Analysis of Traditional Chinese Medicine

作　　者：张俊杰[1] 贾金萍[1] 秦雪梅[2] 

机构地区：[1]山西大学大型科学仪器中心,山西太原030006 [2]山西大学中医药现代研究中心,山西太原030006

出　　处：《分析测试学报》2017年第5期579-587,共9页Journal of Instrumental Analysis

基　　金：国家自然科学基金面上项目(31570346)

摘　　要：中药是中华传统医学的瑰宝,在我国已广泛应用于疾病预防和治疗中,但其存在化学成分复杂、作用机制不明确等问题,制约了中药现代化及国际化的发展进程。质谱技术具有高灵敏度、高选择性、高稳定性及高通量的特点,特别适合于中药复杂成分及其代谢物的定性定量分析。该文综述了近年来质谱技术在中药成分鉴定及质量控制、中药代谢组学及中药药代动力学研究方面的典型应用,并对存在的问题及改进方法进行了展望。Traditional Chinese medicine（TCM） is a treasure of Chinese medical science, and it has been widely applied in the prevention and treatment of disease at home for century. Owing to the reasons that the gradient of TCM is complex and the mechanism of drug efficiency is not clear, the process of modernization and internationalization for TCM has been restricted seriously. With the advantages of high sensitivity, high selectivity, high stability and high-throughput, mass spectrometric （MS） technology is especially suitable for the qualification and quantitation of complex components and their metabolites in TCM. In this paper, the typical application research of MS technology in composition identification and quality control, metabolomics and pharmacokinetics of TCM study in recent years are reviewed, and the problems existed and the improvements are discussed.

关 键 词：质谱(MS) 中药 质量控制 代谢组学 药代动力学 

分 类 号：O657.63[理学—分析化学] TQ460.72[理学—化学]