平阳霉素壳聚糖温敏原位凝胶的制备及体外评价  

Preparation and in vitro evaluation of Pingyangmycin loaded chitosan thermogels

作　　者：陈奋[1] 贾连群[1] 秦兴军[2] 潘卫三[3] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]上海交通大学医学院附属第九人民医院,上海200011 [3]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国医院药学杂志》2017年第9期792-796,共5页Chinese Journal of Hospital Pharmacy

基　　金：辽宁省科学技术计划项目(编号:2010225034);辽宁省科技厅博士科研启动基金项目(编号:201601186)

摘　　要：目的:制备平阳霉素壳聚糖温度敏感型原位凝胶,并进行流变学性质研究及体外评价。方法:采用流变仪考察平阳霉素原位凝胶体系的流变学性质。通过体外释放及体外降解研究,对制剂进行体外评价。结果:流变学研究表明,随着温度升高到37℃左右时,原位凝胶溶液发生了从溶液向凝胶的相转变过程。体外释药的研究表明,药物能持续释放10 d以上,累积释放量达到85%以上。结论:以上结果表明平阳霉素原位凝胶符合介入栓塞要求,体外具有明显缓释效果。OBJECTIVE To prepare pingyangmycin-loaded chitosan thermogels and study the rheological properties,in vitro release behaviors and in vitro degradation.METHODS Rheometer was used to investigate rheological properties of pingyangmycin thermogels.In vitro release and in vitro degradation were studied for evaluation of pingyangmycin thermogels.RESULTS As the temperature raised to 37 ℃,pingyangmycin thermogels would transform from liquid phase to gel phase.In vitro release studies indicated that pingyangmycin could slowly release for more than10 days,and the cumulative release quantity could be up to 85%.CONCLUSION Pingyangmycin thermogels can meet the embolism requirements and have extended release effects in vitro.

关 键 词：平阳霉素 壳聚糖 温敏原位凝胶 流变学 体外评价 

分 类 号：R944[医药卫生—药剂学]