药动学-药效学模型在临床合理用药的应用价值分析  

Value of pharmacokinetics-pharmacodynamics model in rational drug use

作　　者：张敏[1,2] 方平飞[1,2] 

机构地区：[1]中南大学湘雅二医院药学部,湖南长沙410011 [2]中南大学临床药学研究所,湖南长沙410011

出　　处：《中国医院药学杂志》2017年第9期881-884,818,共5页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:81473411;81573686)

摘　　要：药动学-药效学(pharmacokinetics-pharmacodynamics,PK-PD)结合模型阐明了时间-药物浓度-效应三者间关系,能较全面地分析和预测特定给药方案下,药物效应随时间的变化情况,对新药研发,药物临床试验及临床合理用药具有重要的参考价值。现从给药方案优化,疗效和不良反应预测,相互作用分析等方面对近年来国内外PK-PD指导临床用药情况进行综述,阐明PK-PD模型对药物合理使用的意义。Pharmacokinetics-pharmacodynamics（PK-PD）combined model explained the relationship of time-effect-drug concentration in mathematical formula,which could comprehensively analyze and predict a time-response relationship in a certain dosage regimen.PK-PD model valued crucially in drug discovery,clinical trails and rational drug use.This paper analyzed the significance of PK-PD model in medication at home and abroad in recent years,concluding dosage regimen optimizing,predicting efficacy or adverse reactions and drug interactions.More importantly,the value of PK-PD model in rational drug use was well demonstrated.

关 键 词：药动学 药效学 合理用药 药动学-药效学模型 

分 类 号：R969.3[医药卫生—药理学]