吸入麻醉应用于犬实验的效果观察  

The Study of the Effect of Inhalation Anesthesia Used in Dogs＇ Experiment

作　　者：向勇平[1,2] 崔辉[1,3] 刘理金 王琳[1,2] 刘爱兵[1,3] 

机构地区：[1]武警总医院医学实验中心,北京100039 [2]锦州医科大学武警总医院研究培养基地 [3]灾害救援医学北京市重点实验室

出　　处：《中国急救复苏与灾害医学杂志》2017年第4期343-345,共3页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：国家863计划基金资助项目（2015AA033904）

摘　　要：目的探讨吸入麻醉应用于犬实验中的麻醉效果。方法将8只Beagle犬进行肌注诱导麻醉后，转入面罩式麻醉机维持麻醉。分别在麻醉前、麻醉后的10、20、60、120min观察犬的生物反射、镇静镇痛效果、肌肉松弛程度以及苏醒时间的情况，并在麻醉前、麻醉后30、60、90、120min抽取静脉血，测其电解质及葡萄糖的水平。结果有效性：犬无眼睑反射，无痛感，对声音刺激不敏感，牵拉四肢无阻力，有角膜、肛门反射；犬的平均苏醒时间为（8．63±1．41）min.安全性：与麻醉开始时相比，体温在麻醉20min开始下降[（38．08±0．25）℃比（37．50±0．12）℃，P〈0．05]，呼吸频率从麻醉10min开始下降[（23．25±3．69）次份比（20．00±0．93）次／分，P〈0．05]，血氧饱和度在麻醉10rain开始下降[（98．00±1．07）％比（95．50±1．25）％，P〈0．05]；呼吸频率与血氧进行pearsons相关分析具有正相关性（P〈0．05）；电解质相应指标及葡萄糖水平趋于正常。结论吸入麻醉在犬实验中是安全有效的。Objective To investigate the anesthetic effect of inhalation anesthesia in dogs＇ experiments. Methods The 8 beagle dogs were injected after induction of anesthesia, to maintain anesthesia mask anesthesia machine. A series time of 10, 20, 60 and 120min were selected to observe biological reflex, sedation and analgesia, muscle relaxation and recovery time of the dogs before and after anesthesia;Venous blood was taken before anesthesia, 30, 60, 90 and 120min after anesthesia, and the level of electrolyte and glucose were measured. Results Effectiveness： The dog has no eyelids, no pain, no sensitivity to sound stimuli, no resistance to pull and stretch of the limbs and corneal, anal reflex; The average recovery time was （8.63 ± 1.41） min. Security：Compared with the beginning of anesthesia, the temperature at the beginning of anesthesia 20min decreased[（38.08 ± 0.25）℃C vs （37.50 ± 0.12）℃ , P 〈 0.05]. Respiratory rate decreased from the start of anesthesia 10min[（23.25 ± 3.69） time/min vs （20.00 ± 0.93） time/rain, P 〈 0.05]. Blood oxygen saturation in anesthesia 10min began to decline[ （98.00± 1.07 ） % vs （95.50± 1.25 ） %, P 〈 0.05]. The respiration rate and the blood oxygen saturation analysis of pearsons has a positive correlation（P 〈0.05）.Electrolyte corresponding indexes and glucose level were remained at the normal level. Conclusions Inhalation anesthesia was safe and effective in dogs ＇ experiments.

关 键 词：吸入麻醉 BEAGLE犬 有效性 安全性 

分 类 号：R614.21[医药卫生—麻醉学]