血清总胆汁酸在新生儿黄疸时浓度的变化及临床意义  

Change of concentration and clinical significance of serum total bile acid in neonatal jaundice

作　　者：乐丹 

机构地区：[1]孝感市妇幼保健院新生儿科,432100

出　　处：《中国实用医药》2017年第11期32-33,共2页China Practical Medicine

摘　　要：目的研究血清总胆汁酸在新生儿黄疸时浓度的变化及临床意义。方法选取49例新生儿黄疸患儿,其中生理性黄疸新生儿29例(生理组),病理性黄疸新生儿20例(病理组),别选49例健康新生儿作为对照组,对三组新生儿的血清总胆汁酸(TBA)、间接胆红素(IBIL)、总胆红素(TBIL)水平进行比较。结果对照组TBA为(9.17±0.69)μmol/L、IBIL为(11.98±2.58)μmol/L、TBIL为(19.04±3.64)μmol/L,生理组TBA为(10.34±0.86)μmol/L、IBIL为(127.68±20.58)μmol/L、TBIL为(160.98±27.68)μmol/L,病理组TBA为(31.67±9.23)μmol/L、IBIL为(201.34±24.65)μmol/L、TBIL为(251.67±29.99)μmol/L,生理组与病理组各指标水平均高于对照组,差异具有统计学意义(P<0.05)。结论新生儿黄疸采用胆红素检测的同时给予总胆汁酸检测时可利于临床对黄疸类型、胆汁淤积程度、肝细胞损伤和黄疸程度等情况进行有效的判断,从而可以有效对新生儿黄疸的早期诊治及预后,可以保证新生儿的健康。Objective To research change of concentration and clinical significance of serum total bile acid in neonatal jaundice. Methods There were 49 children patients with neonatal jaundice, including 29 newborn with physiologic jaundice （physiologic group） and 20 newborn with pathologic jaundice （pathologic group）, and another 49 healthy newborn as control group. Comparison was made on serum total bile acid （TBA）, indirect bilirnbin （IBIL） and total bilirubin （TBIL） levels in the three groups. Results The control group had TBA as （9.17±0.69） μmol/L, IBIL as （11.98 ± 2.58） μmol/L, and TBIL as （19.04± 3.64） μmol/L. The physiologic group had TBA as （10.34 ± 0.86） μmol/L, IBIL as （127.68 ± 20.58） μmol/L and TBIL as （160.98± 27.68） μmol/L. The pathologic group had TBA as （31.67 ± 9.23） -mol/L, IBIL as （201.34 ± 24.65） μmol/L, and TBIL as （251.67 ± 29.99） μmol/L. The physiologic group and the pathologic group had all higher index levels than the control group, and their difference had statistical significance （P〈0.05）. Conclusion Detection of bilirubin along with total bile acid in neonatal jaundice is helpful for effective judgment of jaundice type, cholestasis degree, hepatocyte damage and jaundice degree, so as to provide effective early diagnosis and prognosis for neonatal jaundice. This method can guarantee neonatal health.

关 键 词：新生儿黄疸 胆素 胆汁酸 浓度变化 

分 类 号：R722.17[医药卫生—儿科]