口服十一酸睾酮胶丸联合麒麟丸治疗男性迟发性性腺功能减退症的临床观察  

Oral Testosterone Undecanoate Capsules combined with Qilin Pills for late-onset hypogonadism in males

作　　者：毛俊彪[1,2] 陈小刚[1,2] 桂定文[1,2] 彭伟[1,2] 张杰[1,2] MAO Jun-biao± CHEN Xiao-gang± GUI Ding-wen± PENG Wei± ZHENG Jie±(Department of Urology, Huangshi Central Hospital / The Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei 435000, China Hubei Key Laboratory for Pathogenesis and Interven- tion of Kidney Diseases, Huangshi, Hubei 435000, China)

机构地区：[1]鄂东医疗集团黄石市中心医院(湖北理工学院附属医院)泌尿外科,湖北黄石435000 [2]肾脏疾病发生与干预湖北省重点实验室,湖北黄石435000

出　　处：《中华男科学杂志》2017年第5期455-458,共4页National Journal of Andrology

基　　金：湖北省卫生厅青年人才项目(QJX2012-51)~~

摘　　要：目的:观察口服十一酸睾酮胶丸联合麒麟丸治疗男性迟发性性腺功能减退症(LOH)患者的临床疗效。方法:符合纳入标准的63例LOH患者随机分为对照组和试验组,对照组口服十一酸睾酮胶丸,试验组口服十一酸睾酮胶丸和麒麟丸。十一酸睾酮胶丸用法:80 mg/次,1次/d,连续服用3个月;麒麟丸用法:6 g/次,3次/d,连续服用3个月。比较组内和组间治疗前后的IIEF-5评分、老年男性症状问卷(AMS)评分及血清总睾酮(TT)水平的变化。结果:两组间各项数据无明显差异(P>0.05)。但治疗后试验组IIEF-5评分(21.7±5.8)分和TT值(16.7±2.2)nmol/L均显著高于对照组(15.9±4.7)分和(13.1±2.8)nmol/L(P<0.05);且AMS评分(20.7±5.7)分显著低于对照组(31.3±6.5)分(P<0.05)。结论:麒麟丸联合十一酸睾酮胶丸治疗LOH的疗效比单用十一酸睾酮胶丸治疗效果更显著,且不增加不良反应发生率,有一定的临床应用前景。Objective ： To investigate the clinical effects of oral Testosterone Undecanoate Capsules （TUC） combined with Qilin Pills （QLP） on late-onset hypogonadism （LOH） in men. Methods： Sixty-three LOH patients meeting the inclusion criteria were ran- domly divided into a control group （aged [48.4 ± 6.2] yr, n = 32） and an experimental group （aged [47.2 ± 5.6] yr, n = 31 ） to be treated with oral TUC （80 rag, qd） and TUC ＋ QLP （6g, tid）, respectively, both for 3 months. Comparisons were made be- tween the two groups of patients in the IIEF-5 scores, total testosterone （TT） levels, and scores in the Aging Males＇Symptoms （AMS） scale before and after treatment. Results： After treatment, the patients of the experimental group, as compared with the controls, showed a significantly increased IIEF-5 score （21.7 ± 5.8 vs 15.9 ± 4.7, P 〈0.05） and TT level （ [16.7 ± 2.2] vs [13.1 ± 2.8] nmol/L, P 〈0.05）, but a decreased AMS score （20.7 ±5.7vs31.3±6.5, P 〈0.05）. Conclusion： TUC combined with Qilin Pills has a better effect and a lower rate of adverse reactions than TUC used alone in the treatment of late-onset hypogonadism in males.

关 键 词：麒麟丸 十一酸睾酮胶丸 迟发性性腺功能减退症 

分 类 号：R588.1[医药卫生—内分泌]