解毒化瘀颗粒结合西医常规疗法治疗登革热临床研究  

Clinical effect ofJiedu-Huayu granule for the degnue fever

作　　者：林路平[1] 刘领弟[1] 刘娇[3] 赵今斋 张复春[2] 谭行华[1] 

机构地区：[1]广州医科大学附属广州市第八人民医院中西医结合科,510060 [2]广州医科大学附属广州市第八人民医院感染科,510060 [3]广州中医药大学热带医学研究所,510006

出　　处：《国际中医中药杂志》2017年第5期402-407,共6页International Journal of Traditional Chinese Medicine

基　　金：国家十二五科技重大专项（2012ZX10004301-003）;广东省中医约局2014年建设中医药强省立项科研项目（20142173）

摘　　要：目的 评价解毒化瘀颗粒结合西医常规疗法治疗登革热的疗效.方法 将符合入选标准的33例登革热患者,采用随机数字表法分为治疗组14例和对照组19例,对照组采用西医常规疗法治疗,治疗组在对照组基础上联用解毒化瘀颗粒.2组均治疗10 d.观察并比较患者并发症的发生率、退热时间、重症及实验室指标的检测结果.结果 治疗前,治疗组血清ALT、AST水平明显高于对照组（t值分别为2.830、2.109,P值分别为0.014、0.044）,但后续治疗中治疗组ALT变化趋势平缓,AST恢复时间缩短,差异无统计学意义（P〉0.05）.治疗组可溶性血管细胞间黏附分子-1（soluble vascular cell adhesion molecule-1,sVCAM-1）在治疗后及治疗后3 d时较对照组同时段升高（t值分别为2.780、2.130,P值分别为0.018、0.460）,后迅速下降.治疗组单核细胞趋化因子-1（monocyto chemotactic protein-1,MCP-1）在治疗后6 d较对照组同时段下降（t=-2.164,P=0.042）.结论 解毒化瘀颗粒联合西医常规疗法可明显减轻登革热患者的肝脏损伤,降低血浆sVCAM-1、MCP-1浓度.Objective To observe the clinical effect ofJiedu-Huayu granule for the Dengue Fever （DF）.Methods The patients with DF were randomly divided into the treatment group and control group. Both groups received the conventional treatment, and the treatment group addedJiedu-Huayu granule. The clinical effects were detected.Results At the baseline, the ALT and AST in the treatment were significantly higher than those in the control group （t=2.830,P=0.014;t=2.109,P=0.044）. But after treatment, there was no difference between groups. The ALT in the treatment group showed a gradual change and AST recovery time showed short. Compared with control group, the concentration of sVCAM-1 in the treatment group was higher at baseline and the third day （t=2.780,P=0.018;t=2.130,P=0.460）, but the concentration of MCP-1 desceased significantly on the 6th day （t=-2.164,P=0.042）.Conclusions Compared with the western medicine, the treatment of western medicine andJiedu-Huayu granule could alleviate liver injure, shorten the recovery time, and reduce the concentration of sVCAM-1 and MCP-1.

关 键 词：登革热 细胞因子类 解毒化瘀颗粒 中西医结合疗法 

分 类 号：R512.8[医药卫生—内科学]