红蓝光联合牛黄上清胶囊治疗中重度痤疮的临床研究  

Research of the clinical effect and immune regulatory mechanism of red blue light combined with Niuhuang-Shangqing capsules for the moderate-severe acne

作　　者：叶艳芬[1] 李洁华[2] 种树彬[1] 周婉云[1] 

机构地区：[1]广东省佛山市南海区人民医院皮肤科,528200 [2]广东省佛山市第一人民医院皮肤科,528200

出　　处：《国际中医中药杂志》2017年第5期416-419,共4页International Journal of Traditional Chinese Medicine

基　　金：佛山市卫生和计生局医学科研课题（2015020）

摘　　要：目的 观察红蓝光联合牛黄上清胶囊治疗中重度痤疮的临床疗效.方法 将符合入选标准的中重度痤疮患者按随机数字表法随机分为2组,每组90例.对照组予以红蓝光交替照射治疗,观察组予以红蓝光交替照射联合牛黄上清胶囊治疗,2组均治疗4周.观察2组临床症状变化、复发率及不良反应发生情况;采用双抗夹心ELISA法检测治疗前后血清中P物质、IL-1、IL-6水平.结果 治疗后,观察组血清P物质水平[（657.4±36.6）pg/ml比（799.9±60.2）pg/ml,t=19.188]、IL-1[（61.8±24.7）pg/比（92.1±23.5）pg/L,t=8.431]、IL-6[（38.7±10.3）pg/ml比（66.7±14.1）pg/ml,t=12.421]低于对照组（P〈0.01）.观察组总有效率为91.11%（82/90）、对照组为70.00%（63/90）,2组比较差异有统计学意义（χ^2=12.804,P〈0.01）.结论 红蓝光联合牛黄上清胶囊治疗中重度痤疮,可降低血清P物质、IL-1、IL-6,总有效率高于对照组.Objective To investigate the the clinical effect and immune regulatory mechanism of red-blue light combined with Niuhuang Shangqing capsules for the moderate-severe acne.Methods A total of 180 patients with moderate to severe acne treated in People＆#39;s Hospital of Nanhai District in Foshan City from June 2014 to June 2016 were randomly divided into 2 groups with each group 90 patients. The control group was treated with red and blue light, and observation group was treated with the combination of red and blue light andNiuhuang-Shangqingcapsules. The levels of SP（Substance P）, IL-1 and IL-6 in peripheral blood were observed and analyzed. The recurrence rates and adverse events were observed.Results After treatment, the SP （657.4 ± 36.6 pg/mlvs.799.9 ± 60.2 pg/ml,t=19.188）, IL-1（61.8 ± 24.7pg/L vs.92.1 ± 23.5 pg/L,t=8.431）, IL-6 （38.7 ± 10.3pg/mlvs.66.7 ± 14.1pg/ml, t=12.421） of the observation group were significantly better than those of the control group （allPs〈0.01）. The total effect rate of the observation group were 91.11% （82/90）, which were significantly higher than 70.00% （63/90） of control group （χ^2=12.804,P〈0.01）. Conclusions The Red-blue light combined withNiuhuang-Shangqing capsules for treating moderate-severe acne, has significant effect and can reduce the serum levels of SP, IL-1 and IL-6, with fewer adverse events and lower recurrence rates. They can be used as a safe and effective treatment of acne.

关 键 词：寻常痤疮 色光疗法 牛黄上清胶囊 免疫 疗效比较研究 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]